Paget样鲍温病1例报告并文献复习.pdfVIP

中国误诊学杂志2008年1月第8卷第1期 Chin J Misdiagn，Jan 2008 Vol 8 No．1 【研究原著】 Paget样鲍温病1例报告并文献复习 丛林，常冬青，杨蓉娅 【摘要】 目的：探讨Paget样鲍温病的组织病理特征、诊断、鉴别诊断、治疗、误诊原因和预防。方法：报道1例Paget 样鲍温病，并结合文献进行复习。结果：Paget样鲍温病组织病理检查兼具鲍温病和乳房外Paget病样改变，主要需与乳 房外Paget病及Paget样原位恶黑等鉴别，手术切除是首选治疗方法。结论：Paget样鲍温病临床罕见，易被误诊，需通过 组织病理检查确诊，对诊断困难的病例尚需通过粘蛋白染色或多种抗体免疫组化染色进行鉴别。 、 【主题词】 佩吉特病，乳腺／病理学／诊断／治疗；误诊；诊断，鉴别；病例报告[文献类型]；人类 【中图分类号】 R730．261 【文献标识码】 A 【文章编号】 1009—6647(2008)01-0015-03 A Case Report of Pagetoid Bowen S Disease and Review Literature CONG Lin，CHANG Dong—Qing，YANG Rong—Ya (Department of Dermatology，General Hospital of Bering Military Command，BeUing 100026，China) [Abstract] Objective：To discuss the histopatho1ogic characteristic、diagnosis、differential diagnosis、treatment、 reasons and preventiOn of misdiagnosis of pagetoid Bowen S disease．Method：A ease of pagetoid Bowen S disease and a review of the literature．Results：The histopatho1ogic changes were similar with Bowen S disease and extramammary Paget S disease．The differential diagnosis included pagetoid Bowen S disease，extramammary Paget S disease and pagetoid malignant melanoma in situ(MIS)，Exc~sion was the first-choice treatment of this diasease．Conclusion：Pagetoid Bowen S disease is rare and easily misdiagnosed clinically，histopatho1。gic examination is needed for diagnosis．Com— bined with mucin stains，a immunohistochemical panel may be of diagnostic value in particularly difficult cases． [MESH】 Paget S Disease，Mammary／pathology／diagnosis／therapy；Diagnostic Errors；Diagnosis，Differential；Case Reports[Pub1ication Type]；Human Paget样鲍温病指组织学上有大型Paget细胞样 质丰富淡染似Paget细胞，核呈圆形或椭圆形。真皮浅 淡染细胞巢形成的鲍温病。该类型鲍温病临床罕见，我