血浆脂联素与冠状动脉病变程度的相关性分析.pdfVIP

北 京 大 学 学 报 ( 医 学 版 ) JOURNAL OF PEKING UNIVERSITY(HEALTH SCIENCES) Vo1．39 No．6 Dec．2007 ·599· 论 著 血浆脂联素与冠状动脉病变程度的相关性分析 王学英 ，郭艳红。，郭丽君 ，高 (1．北京大学第三医院心内科，北京 100083；2．北京煤炭总医院心脏中心) [摘 要】目的：通过测定冠状动脉造影患者的血浆脂联素(adiponectin，APN)浓度，进一步探索其对冠状动脉病变 的影响。方法：收集105例冠状动脉造影患者的术前血浆，采用酶联免疫法测定APN浓度，冠状动脉病变程度用病 变血管支数和Gensini积分表示。结果：正常组APN浓度显著高于单支、双支、三支病变组(P值分别为0．012、 0．0O4、0．000 5)，且随病变支数的增加，APN浓度有逐渐降低趋势。Gensini积分930分组APN浓度明显低于30 分组及0分组(P0．05)。急性冠状动脉综合征组(acute coronary syndrome，ACS)APN浓度明显低于非ACS组 [(0．731 4-0．361)mg／L与(1．097 4-0．617)m#L，P=0．03)。Logistic回归分析证实，低水平APN浓度是冠状动脉 狭窄及斑块不稳定的独立危险因素。冠心病危险因素相关分析显示，APN与高密度脂蛋白胆固醇(high density lip— oprotein cholesterol，HDL-C)呈正相关，与甘油三脂(triglyceride，TG)、C反应蛋白呈负相关。结论：血浆APN水平与 冠状动脉粥样硬化及其严重程度和斑块稳定性独立相关，同时与C反应蛋白、TG、HDL—C也存在明确关系。 [关键词】脂联素；冠状动脉硬化；冠状动脉狭窄 [中图分类号]R541．4 [文献标识码]A [文章编号】1671—167X(2007)06-0599-04 Association between plasma adiponectin levels and coronary lesion complexity WANG Xue—ying ，GUO Yan—hong ，GUO Li-jun ，GAO Wei (1．Department of Cardiology，Peking University Third Hospital，Beijing 100083，China；2．Heart Center，Beijing Coal General Hospita1) ABSTRACT 0bjective：To explore the association between the levels of plasma adiponectin and coro— nary artery lesion complexity in patients undergoing coronary angiography．Methods：We measured the Dlasma concentrations of adiponectin in 1 05 candidates I 28 healthy controls and 77 patients with coronary artery diseases(CAD)]．The complexity of coronary artery lesion was evaluated by the numbers of vessel disease and Gensini score．Results：Plasma concentrations of adiponectin in healthy group were signifi— cantly higher than those in CAD patients．Among patients with CAD．those with multiple vessel lesions had significanfly lower adiponectin levels than those with a single vessel lesion．Plasma concentrations of adiponectin in Gensini score≥