毛鸡骨草叶中一个新的吐昔酰胺类成分one new truxillic - 药学学报.pdf

药学学报 Acta Pharmaceutica Sinica 20 16, 51 ( 10): 1595 1599 ·1595 · 鸡骨草叶中一个新的吐昔酰胺类成分 * 袁旭江, 张 平, 李春阳, 霍务贞, 鲁湘鄂, 吴燕红 (广东 科大学中药开发研究所, 国家中医 管理局中药制剂三级实验室, 广东 广州 510006) 摘要: 毛鸡骨草 (Abrus mollis Hance) 叶采用水醇提取, 不同有机溶剂萃取, 获得正丁醇部位, 利用各种柱 色谱技术进行分离纯化, 理化性质结合UV 、MS 、TLC 、HPLC 和NMR 等波谱技术鉴定出6 个化合物, 分别为: 葫芦巴碱 (1) 、脯氨酸 (2) 、丙氨酸酐 (3) 、顺式-N-(4-羟基桂皮酰) 氨酸 (4) 、反式-N-(4-羟基桂皮酰) 氨酸 (5) 和鸡骨草丙素 (6) 。化合物6 为新化合物, 化合物1～4 均是首次从该植物中分离得到。 关键词: 毛鸡骨草; 化学成分; 鸡骨草丙素; 酰胺类 中图分类号: R284 文献标识码: A 文章编号: 0513-4870 (20 16) 10- 1595-05 One new truxillic amide compound from Abr us mollis leaves * YUAN Xu-j iang , ZHANG Ping, LI Chun-yang, HUO Wu-zhen, LU Xiang-e, WU Yan-hong (Research and Development Institute of Chinese Materia Medica, Guangdong Pharmaceutical University/ Class III Laboratory of Modern Chinese Medicine Prep aration, State Administration of Traditional Chinese Medicine of the P.R.C., Guangzhou 510006, China ) Abstract : The butanol extract part was extracted and isolated with water, alcohol and different organic solvents from Abrus mollis leaves. 6 compounds were isolated and purified using various column chroma- tographies and identified with the spectral techniques such as UV, MS, TLC, HPLC and NMR. The structures of 6 compounds were trigonelline ( 1), praline (2), alanine anhydride (3), (Z)-N -(4-hydroxycinnamoyl)tyrosine (4), (E)-N -(4-hydroxycinn