单磷酸阿糖腺苷合成方法改进.pdf

- 98 - 銆婃寜鎽╀笌搴峰鍖诲銆?013 骞? 鏈堢4 鍗风2 鏈 Chinese Manipulation Rehabilitation Medicine,Feb.2013,Vol.4No.2 鈥㈣嵂瀛︾爺绌垛€ 鍗曠７閰搁樋绯栬吅鑻峰悎鎴愭柟娉曟敼杩涘崟纾烽吀闃跨硸鑵鸿嫹鍚堟垚鏂规硶鏀硅繘 闄堥搧閽庯紝闄堟爲鍩庯紝鍙堕泚娉 锛堝箍涓滅渷鐢熺墿鍒跺搧涓庤嵂鐗╃爺绌舵墍锛屽箍涓滃箍宸?10440锛 [[鎽樻憳 瑕佽]] 鍗曠７閰搁樋绯栬吅鑻锋槸涓€绉嶆姉DNA 鐥呮瘨鑽墿锛岀洰鍓嶄粛骞挎硾搴旂敤浜庣敱鐥呮瘨寮曡捣鐨勭柧鐥呮不鐤椼€傛湰璇鹃 閫氳繃璋冩暣鍘熸枡鍜屽弽搴旇瘯鍓傜殑姣斾緥浠ュ強鍙嶅簲鏃堕棿绛夊鍗曠７閰搁樋绯栬吅鑻风殑鍚堟垚宸ヨ壓杩涜鏀硅繘锛岀畝鍖栦簡鎿嶄綔姝ラ锛屾彁 楂樹簡浜у搧鐨勬敹寰楃巼鍜岃川閲忋€ [[鍏抽敭璇嶅叧閿瘝]] 鍗曠７閰搁樋绯栬吅鑻凤紱鍚堟垚锛涗笁姘哀纾风敤閲 [[涓浘鍒嗙被鍙蜂腑鍥惧垎绫诲彿]R]R978978..77锛涳紱RR962962 [[鏂囩尞鏍囪瘑鐮佹枃鐚爣璇嗙爜]B]B [[鏂囩珷缂栧彿鏂囩珷缂栧彿]])0202--0202 TheThe ImprovementImprovement aboutabout SynthetizeSynthetize MethodsMethods ofof VidarabineVidarabine MonophosphateMonophosphate CHEN Tie-qian, CHEN Shu-cheng, YE Yan-bo (Guangdong provincial Institute of Biological Products And Materia Medica, Guangzhou, Guangdong, 510440) AbstractAbstract Vidarabine monophosphate is an anti-DNA virus drug. It still widely uses in the treat- ment of the disease caused by viruses. This project improved the synthesis technology of vidarabine monophosphate by adjusting the proportion of raw materials and reaction reagent, response time, etc. Simplified the operation steps and improved the yield and quality of product. KeywordsKeywords vidarabine monophosphate; synthetize; dosage of phosphorus oxychloride 鍗曠７閰搁樋绯栬吅鑻?vidarabine monophosphate锛夛紝 鐥咃級鐨勬不鐤楋紝鏄箍璋辨姉鐥呮瘨鑽€傜洰鍓嶏紝鍗曠７閰搁樋绯栬吅 鍖栧鍚嶏細9-(尾-D- 闃挎媺浼憢鍠冪硸)- 鑵哄槍鍛?5 鈥?鍗曠７閰 鑻峰悎鎴愭柟娉曠殑鎶ラ亾寰堝[6-7] 銆傛垜浠湁20 澶氬勾缁勭粐涓 閰紝涓烘姉鑴辨哀鏍哥硸鏍搁吀鐥呮瘨鑽墿銆傚崟纾烽吀闃跨硸鑵鸿嫹 鎸佽浜у搧鐨勭敓浜х粡楠屻€傜幇鎶婂叾鍚堟垚鏂规硶鐨勬敼杩涙姤 鏄簩绫昏嵂锛屼负鎴戝浗鍑犱釜鎶楃梾姣掕タ鑽腑鐨勪竴涓紝85 骞 鍛婂涓嬨€傛湰鏂规硶涓嶇敤閲嶇粨鏅讹紝鏀剁巼98% 浠ヤ笂銆傚寲瀛 鍦ㄥ箍涓滅渷鑽墿鐮旂┒鎵€鐮斿彂鎴愬姛銆傚崟纾烽吀闃跨硸鑵鸿嫹