从毒论治急性胰腺炎的临床研究和机制探讨.pdfVIP

提 要 目的：本研究通过从毒论治急性胰腺炎 （Acute pancreatitis AP ），观察临床疗效， 从而探讨 AP 从毒论治的合理性、正确性及可靠性，以指导临床。方法：共选观察对 象60例，随机分为两组，试验组（30例）在西医综合治疗基础上予祛毒安胰汤口服； 对照组（30例）予西医综合治疗。10天为一疗程，分别观察治疗前后中医证候积分、 临床综合疗效以及内毒素、IL-6、TNF- α、白细胞计数、血淀粉酶（PAMY ）、尿淀 粉酶(UAMY)、CT、血钙、血糖等指标。结果：中医证候积分：两组均降低，试验组 明显优于对照组,具有统计学意义（p0.05或 p0.01）；临床综合疗效：尽管有效率 方面，两组无统计学差异（p0.05），但愈显率方面，试验组优于对照组，具有统计 学差异（p0.05）；实验室指标：治疗后，两组中内毒素、TNF- α、血糖、UAMY 恢 复正常时间均降低或缩短，试验组优于对照组，且具有统计学意义（p0.05）；IL-6、 白细胞计数均降低，但两组比较无统计学差异（p0.05）；PAMY 恢复时间、血钙方 面，两组无统计学差异（p0.05 ）。 结论：从毒论治急性胰腺炎取得了满意的结果，为中医治疗 AP 提供了有效的方 法和思路。 关键词 急性胰腺炎；中医药；从毒论治；临床研究 The Theoretical and Clinical Research of Acute Pancreatitis based on Toxin Theory Speciality: Chinese Internal Medicine Author: Kao Yan-lei Tutor: Professor Chi Li-li Abstract Objective: This study is carried out by clinical research of Acute Pancreatitis based on toxin theory to investigate the reasonable, the accuracy and reliability of treating AP with the detoxification principle of Traditional Chinese Medicine, to guide clinical. Method: A total of 60 cases observed objects selected randomly were divided into two groups, experimental group (30 cases) in the treatment of Anyiqudutang on the basis of Western medicine treatment and the control group (30 cases) to the TCM and Western medicine treatment. Cases were selected for 10 days as a course, whose symptoms including TCM syndrome score, comprehensive clinical efficacy, endotoxin, IL-6, TNF-α, white blood cell count, PAMY, UAMY, CT, Ca, Glu. Results: Comparison of TCM symptom scores: both groups decreased, and the experimental group was more obvious than the