美他多辛治疗酒精性脂肪肝临床观察.docVIP

美他多辛治疗酒精性脂肪肝临床观察[摘要] 目的：观察美他多辛治疗酒精性脂肪肝的临床疗效。方法：将酒精性脂肪肝患者68例随机分为两组，观察组38例给予美他多辛片500 mg，每日2次口服；对照组30例给予甘利欣片150 mg，每日3次口服，疗程均为3个月。结果：美他多辛治疗酒精性脂肪肝可明显改善患者的临床症状，总有效率为94.7%，与对照组相比有显著性差异（P＜0.05）。结论：美他多辛可有效改善酒精性脂肪肝患者的临床症状和肝功能，可降低血脂，且无严重不良反应，值得临床推广。 [关键词] 美他多辛；酒精性脂肪肝 [中图分类号] R５７５.5[文献标识码]C [文章编号]1673-7210（2008）11（a）-057－０2 Clinical investigation on treatment of alcoholic fatty liver with Metadoxine ZHAO Wei1,CHENG Chun-yan2,YANG Guang1 (1.Department of Digestion, Harbin First Hospital, Harbin150010,China; 2.Heilongjiang Forest Industry General Hospital, Harbin150010, China) [Abstract] Objective: To observe the clinical effect of alcoholic fatty liver with Metadoxine. Methods: Alcoholic fatty liver patients were randomly divided into two groups of 68 cases, 38 cases suffering from alcoholic fatty liver were treated with Metadoxine tablets 500 mg bid po, and 30 cases in control group were treated with DiammoniumGlycyrrhizinate tablets 150 mg tid po in 3 months of treatment. Results: Metadoxine ameliorated the clinical symptoms of alcoholic fatty liver, with the total efficacy of 94.7%, compared with the control group were significantly different (P＜0.05). Conclusion: Metadoxine can ameliorate the clinical symptoms and the liver function and plasma triglyceride and cholesterol of alcoholic fatty liver, and deserve extensive application without severe side effects. [Key words] Metadoxine; Alcoholic fatty liver 近年来，随着酒精消耗量的增加，酒精性肝病的发病率越来越高。酒精性肝病包括轻症酒精性肝病、酒精性脂肪肝、酒精性肝炎、酒精性肝纤维化及酒精性肝硬化。该病是我国常见的肝脏疾病之一，严重危害人民健康，其中以酒精性脂肪肝（alcoholic fatty liver，AFL）最为常见，其发展为酒精性肝硬化的危险性比单纯脂肪肝高。目前，临床尚无特效药物治疗，我院采用美他多辛治疗AFL取得了满意疗效，现报道如下： 1资料与方法 1.1临床资料 收集我院近3年来住院及门诊患者68例，设观察组38例，对照组30例。观察组男33例，女5例，年龄28～60岁，平均43.5岁；对照组男19例，女11例，年龄24～58岁，平均41.5岁。 1.2诊断标准 饮酒时间超过5年；折合酒精量男性每日大于40 g，女性每日大于20 g，或2周内有大量饮酒史，酒精量每日大于80 g；肝功能损害（ALT＞40 U/L，AST＞40 U/L，GGT＞54 U/L）；血脂异常（TC＞6.0 mmol/L，TG＞2.3 mmol/L）；超声改变肝脏肿大，近场回声密度增强，远场回声衰减，血管纹理不清晰；排除病毒性、药物性、寄生虫及代谢性异常等引起的肝损伤。 1.3方法 观察组给予美他多辛片（甘忻，山东齐鲁药业