赖氨匹林在急诊儿科发热性疾病中应用观察.docVIP

赖氨匹林在急诊儿科发热性疾病中应用观察[摘要] 目的：观察赖氨匹林对小儿高热的退热效果。方法：选择200例高热患儿，将其随机分为赖氨匹林组和安痛定组，分别用赖氨匹林和安痛定肌注退热，观察体温变化，进行疗效比较。结果：两组患儿用药30 min及1 h后观察体温变化，赖氨匹林组显效率分别为84.7%和98.0%，安痛定组显效率分别为40.0%和86.0%，赖氨匹林组退热效果优于安痛定组，且观察期间无不良反应发生。结论：赖氨匹林起效快，效果好，疗效肯定，无不良反应，是治疗小儿高热的有效药物。 [关键词] 赖氨匹林；小儿高热；退热；急诊 [中图分类号] R72 [文献标识码]B[文章编号]1674-4721（2011）08（a）-061-02 Application observation of aspisol in the treatment of febrile disease in pediatric emergency department Siergeling, Asiya Pa-taer Department of Emergency, Children′s Hospital of Urumqi, Xinjiang Uygur Autonomous Regions, Urumqi 830000, China [Abstract] Objective: To observe the antipyretic effect of aspisol on children with high fever. Methods: 200 children with high fever were selected and randomly divided into two groups. Aspisol and Alidine were intramuscularly injected for each group. The changes of temperature were observed and the clinical effects were compared. Results: The changes of temperature for both groups were observed 30 minutes and 1 hour after dosing, the effective rate of Aspisol group and Alidine group were 84.7%, 98.0% and 40.0%, 86.0% respectively. The cooling effect of Aspisol group was better than Alidine group, and no adverse effect was occurred during the observation period. Conclusion: Aspisol has a rapid onset and positive effect, no adverse effect, which make it an effective drug in the treatment of children with high fever. [Key words] Aspisol; Children with high fever; Antipyretic; Emergency treatment 高热是急诊儿科最常见的症状，也是多种疾病的临床表现之一。小儿神经系统发育不完善，对体温的调节能力有限。持续的高热能引起机体调节功能紊乱外，极易引起高热惊厥，将给患儿身体带来一定损害，甚至危及生命。对发热的患儿除了及时查找原因、病因治疗外，更应积极给予快速有效、安全持久的退热处理。本院急诊儿科于2010年1～3月应用赖氨匹林治疗小儿高热，并与安痛定作为对照观察其体温变化、退热时间、疗效加以比较，观察期间无一例不良反应发生。现将取得的良好效果报道如下： 1 资料与方法 1.1 一般资料 全部病例均来自本院急诊儿科高热患儿，共200例，年龄5个月～12岁，体温波动在38.5～41.0℃，其中，男105例，女95例。病种上呼吸道感染103例，下呼吸道感染88例，感染性腹泻9例。将200例患儿随机分两组，赖氨匹林肌注组150例，安痛定肌注组50例。 1.2 用药剂量与方法 赖氨匹林系海南皇隆制药厂生产，规格0.25 g/支，剂量15～20 mg/（kg?次），肌注用NS配制成2 ml。安痛定肌注组用量，6个月～1岁0.50~0.75 ml/次，2～3岁0.80~1.25 m