活性牡蛎丸对绝经后妇女临床症状及骨吸收的影响.pdfVIP

维普资讯 C · 1807 · · 短 篇 论 著 · 活性牡蛎丸对绝经后妇女临床症状及骨吸收的影响 周广华，张宏印，张凤霞，徐京昕 【摘要】 目的 观察活性牡蛎丸对绝经后妇女临床症状及骨吸收的影响。方法 将56例绝经后妇女随机分为两 组，治疗组服用活性牡蛎丸，对照组服用谷维素片，均用药9个月，分别记录和检测用药前、后两组妇女临床症状和 尿中骨组织代谢产物I型胶原N末端肽 (NTx)的浓度。结果 治疗组患者服用牡蛎丸后 ，头痛、头晕、胸闷、烦躁、 潮热出汗、阴道不适、外阴干痛、肌肉痉挛、骨关节痛等症状明显改善；用药前、后两组妇女尿NTx值间差别均无显 著性意义 (P0．05)，但治疗组妇女中NTx异常者用药前、后NTx值间差别有显著性意义 (P0、01)。结论 活性 牡蛎丸对绝经后妇女更年期症状改善有一定作用。 【关键词】 活性牡蛎丸；绝经期；骨吸收；I型胶原N末端肽 【中图分类号】R7l1 R287．4 【文献标识码】B 【文章编号】1007—9572(2006)21—1807—02 InfluencesofActiveOysterPillonClinicalSymptomsandBoneAbsorptioninPostmenopausalW omen ZHOU Guang— hua，ZHANGHong—yin，ZHANGFeng—xia，eta1．PekingUniversityHospital，Be ng100871，China A【bstract】 Objective Toobservetheinfluencesofactiveoysterpillonthepostmenopausalwomensclinicalsymptoms andabnormalbasorptionofbones、Methods Totally56postmenopausalwomenwerechosenanddividedintotwogroupsrandom- ly，trialrgoupwastreatedwithhteactiveoysterpillandconrtolrgoupwiht oryzanoltbaletsfor9monhts、TheconcenrtationsofN — telopeptideofTypeICollagen(NTx)intheurineofhtesubjectsintworgoupbeforeandafterrteatmentweremeasured，nad hteirclinicalsymptomswererecordedrespectively．Results Th esymptomsofhtesubjectsintrialgroupsuchasheadache，diz- ziness，chestdisrtess，dysphoria，tidal feverwiht perspiration，vaginal discomfort，pudendal drynessnad pain，myospasm ， arthralgia，etcwerealleviatedobviously．Th ereisnosignificnatdifferenceinurinaryNTxconcenrtationbetweenhtewtorgoups beforeandaftertreatments(P0，05)．However，after9monhtsrteatment，singificantdifferenceinurinaryNTxconcenrtation wasobservedinthepatientswhohadalreadyshowedcertainbanomralbeforehterteatments(P 0、01)．Conclusion Active oysterpillhasacertaineffectson improvingtheclinicalsymptomsofpostmenopausal women、 K【eywor