characteristics of non-small cell lung cancer located in the right middle lobe according to a retrospective study of recurrence and prognosis非小细胞肺癌的特征位于右侧中部叶根据复发和预后的回顾性研究.pdfVIP

characteristics of non-small cell lung cancer located in the right middle lobe according to a retrospective study of recurrence and prognosis非小细胞肺癌的特征位于右侧中部叶根据复发和预后的回顾性研究.pdf

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characteristics of non-small cell lung cancer located in the right middle lobe according to a retrospective study of recurrence and prognosis非小细胞肺癌的特征位于右侧中部叶根据复发和预后的回顾性研究

Open Journal of Thoracic Surgery, 2012, 2, 52-57 / 10.4236/ojts.2012.23012 Published Online September 2012 (http://www.SciRP.org/journal/ojts) Characteristics of Non-Small Cell Lung Cancer Located in the Right Middle Lobe According to a Retrospective Study * of Recurrence and Prognosis # Katsuhiko Shimizu , Yuji Hirami, Riki Okita, Shinsuke Saisho, Takuro Yukawa, Ai Maeda, Koichiro Yasuda, Masao Nakata Department of General Thoracic Surgery, Kawasaki Medical School, Kurashiki, Japan. Email: #kshimizu@med.kawasaki-m.ac.jp Received May 11th, 2012; revised June 11th, 2012; accepted June 20th, 2012 ABSTRACT Background: Some studies have suggested that among all cases of lung cancer, the outcome of lung cancer located in the right middle lobe (RML) is the worst. However, with the advances in the diagnosis and treatment methods of lung cancer over the last couple of decades, we investigated whether the prognosis of primary lung cancer located in the RML still remains inferior to that of lung cancer arising from other lobes. Methods: Between July 2003 and December 2011, 505 consecutive patients with non-small cell lung cancer (NSCLC) underwent surgical resection at our institution. Of these, 32 patients (6.3%) had tumors arising from the RML. Results: The rate of incomplete resection was higher for cancer located in the RML than that for cancer arising from other lobes. Significant associations were noted between cancer located in the RML and the rate of lymph node metastasis and initial locoregional recurrence. Multivariate analysis identified lymph node metastasis and location in the RML as independent risk factors influencing the recur- rence-free survival (p = 0.006), although location in the RML was not extracted as an independent risk factor influence- ing the overall survival (p = 0.060). Conclusion: Despite the recent

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