原创力文档characteristics of plasmacytoid dendritic cell and cd4+ t cell in hiv elite controllers特征的血浆树突细胞和cd4 + t细胞在hiv精英控制器.pdfVIP
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characteristicsofplasmacytoiddendriticcellandcd4tcellinhivelitecontrollers特征的血浆树突细胞和cd4t细胞在hiv精英控制器
Hindawi Publishing Corporation
Clinical and Developmental Immunology
Volume 2012, Article ID 869505, 8 pages
doi:10.1155/2012/869505
Review Article
Characteristics of Plasmacytoid Dendritic Cell and
CD4+ T Cell in HIV Elite Controllers
1 ¨ 2 ` 3
Jean-Philippe Herbeuval, Nikaıa Smith, and Jacques Theze
1 CNRS UMR 8147 and Hopital Necker, Universite Paris Descartes, 149-161 rue de Sevres,
ˆ ´ `
75015 Paris, France
2 CNRS UMR 8601, Universite Paris Descartes, 45 rue des Saint-Peres, 75006 Paris, France
´ `
3 Unite d’Immunologie Humaine, Centre Medical Necker Pasteur, Institut Pasteur, 28 Rue du Docteur Roux,
´
75015 Paris, France
Correspondence should be addressed to Jean-Philippe Herbeuval, jean-philippe.herbeuval@parisdescartes.fr
Received 21 August 2012; Revised 22 October 2012; Accepted 23 October 2012
Academic Editor: Vicki L. Traina-Dorge
Copyright © 2012 Jean-Philippe Herbeuval et al. This is an open access article distributed under the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is
properly cited.
Despite variability, the majority of HIV-1-infected individuals progress to AIDS characterized by high viral load and massive CD4+
T-cell depletion. However, there is a subset of HIV-1-positive individuals that does not progress and spontaneously maintains
an undetectable viral load. This infrequent patient population is defined as HIV-1 controllers (HIV controll
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