effect of aggressive early high-dose intravenous amino acid infusion and early trophic enteral nutrition on very low birth weight infants积极的影响早期大剂量静脉注射氨基酸输液和早期营养肠内营养对极低出生体重婴儿.pdfVIP

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effect of aggressive early high-dose intravenous amino acid infusion and early trophic enteral nutrition on very low birth weight infants积极的影响早期大剂量静脉注射氨基酸输液和早期营养肠内营养对极低出生体重婴儿.pdf

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effect of aggressive early high-dose intravenous amino acid infusion and early trophic enteral nutrition on very low birth weight infants积极的影响早期大剂量静脉注射氨基酸输液和早期营养肠内营养对极低出生体重婴儿

Food and Nutrition Sciences, 2012, 3, 1604-1608 1 /10.4236/fns.2012.311209 Published Online November 2012 (http://www.SciRP.org/journal/fns) Effect of Aggressive Early High-Dose Intravenous Amino Acid Infusion and Early Trophic Enteral Nutrition on Very Low Birth Weight Infants 1,2 2,3* 4 4 2 Man-Yau Ho , Yu-Hsuan Yen , Hsiang-Yin Chen , Shu-Chen Chien , Mao-Chih Hsieh , Yao-Shun Yang1 1Department of Pediatrics, Taipei, Chinese Taipei; 2Nutritional Support Team, Taipei, Chinese Taipei; 3Pharmacy, Taipei Medical University—Wan Fang Hospital, Taipei, Chinese Taipei; 4Department of Clinical Pharmacy, Taipei Medical University, Taipei, Chi- nese Taipei. * Email: sandrayen@.tw Received September 9th, 2012; revised October 9th, 2012; accepted October 16th, 2012 ABSTRACT Objective: Very-low-birth-weight (VLBW) preterm infants are at risk of growth delay if they do not receive adequate nutritional support. This study evaluated the effect of aggressive early high-dose amino acid infusion plus early enteral trophic feeding on growth in VLBW infants within the first day of life. Study Design: The effect of a high-dose 3 g amino acid (HAA)/kg/d regimen beginning on the first day of life was compared with that of low-dose amino acid (LAA) supplementation at a dose of 0.5 or 1.0 g/kg/d. The primary outcome measures were the days of regained birth weight and achieved full enteral feeding. Result: Compared with the 19 infants in the LAA group, the 17 infants in the HAA group achieved significantly earlier full enteral feeding (7.8 ± 3.6 vs. 15.2 ± 8.9, p = 0.003) and regained birth weight (13.3 ± 3.8 vs. 17.5 ± 7.9, p = 0.047). In addition, shorter parenteral nutrition time was achieved by H