effect of a rotating frame on preventing bead aggregation in a microfluidic device旋转框架对防止珠聚合的影响在微流控装置.pdfVIP

Advances in Bioscience and Biotechnology, 2012, 3, 603-608 ABB /10.4236/abb.2012.35078 Published Online September 2012 (http://www.SciRP.org/journal/abb/) Effect of a rotating frame on preventing bead aggregation in a microfluidic device 1 2 1* Jie Yang , Peter B. Howell, Jr. , Nastaran Hashemi 1Department of Mechanical Engineering, Iowa State University, Ames, USA 2Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington DC, USA * Email: nastaran@ Received 11 June 2012; revised 20 July 2012; accepted 18 August 2012 ABSTRACT rectly into a rapid on-bead oligomer-target screening platform because they tend to settle quickly [7]. There- Varying bead concentrations over the course of ex- fore, Price et al. used tall, capped cartridges containing periments have been reported by many scientists. A the one-bead-one-compound library to introduce beads new device was designed and developed to eliminate into their platform. In a bead capture study by Lund- bead aggregation in a syringe pump prior to flowing Olesen et al., it is shown that a microfluidic mixer inte- through a microchannel. We have modeled the effects grated with a passive