effects of structural modification of anti-inflammatory steroidal antedrug on pro-inflammatory mediators and inhibitory cytokines in human alveolar epithelial cells结构修改的影响抗炎甾族的antedrug炎性介质和抑制性细胞因子在人类肺泡上皮细胞.pdfVIP

Vol.1, No.3, 127-133 (2009) Health doi:10.4236/health.2009.13021 Effects of structural modification of anti-inflammatory steroidal antedrug on pro-inflammatory mediators and inhibitory cytokines in human alveolar epithelial cells 1 2 1 2 3 Gui-Fang Wang , Soonjo Kwon *, Rakesh Sharma , Hemang Patel , Henry J. Lee 1Chemical and Biomedical Engineering, Florida State University, Tallahassee, USA; soonjo.kwon@ 2Biological Engineering, Utah State University, Logan, USA 3Center for Anti-Inflammatory Research, College of Pharmacy and Pharmaceutical Sciences, Florida AM University, Tallahassee, USA Received 23 September 2009; revised 19 October 2009; accepted 20 October 2009. ABSTRACT further reduced NO production to 39%. In con- clusion, a synthesized steroidal antedrug FP- The anti-inflammatory effects of the new ster- ISO-21AC showed higher anti-inflammatory ef- oidal antedrug, 21-acetyloxy-9α-fluoro-11β-hy- fects than PRED by inhibiting the expression of droxyl-3, 20-dioxo-1, 4-pregnadieno-[16α, 17α-d] pro-inflammatory mediator NO and stimulating isoxazoline (FP-ISO-21AC), on nitric oxide (NO) the expression of IL-22R. and interleukin 8 (IL-8) production, were inves- tigated together with its parent steroid predni- Keywords: Steroidal Antedrug; NO Production; solone (PRED). PRED is one of the anti-in- IL-8 Production; Anti-Inflammatory Cytokine Receptor; flammatory steroids but has systemic side ef- IL-22 Receptor fects which limit the use of it. PRED was mod