selection of adjuvants for enhanced vaccine potency选择增强佐剂的疫苗效力.pdfVIP

World Journal of Vaccines, 2011, 1, 33-78 1 doi:10.4236/wjv.2011.12007 Published Online May 2011 (http://www.SciRP.org/journal/wjv) Selection of Adjuvants for Enhanced Vaccine Potency 1 2 Wei Wang , Manmohan Singh 1BioTherapeutics Pharmaceutical Sciences, Pfizer Inc, Chesterfield, USA; 2Novartis Vaccines and Diagnostics, Cambridge, USA. Email: wei.2.wang@ Received February 16th, 2011; revised March 17th, 2011; accepted March 25th, 2011. ABSTRACT The advent of mass vaccination has saved millions of human lives and revolutionized the quality of life. Vaccination is currently one of the most cost effective ways of managing healthcare costs in both emerging and developed countries. Despite the long vaccine history and success, design and development of efficacious and safe vaccines has been tradi- tionally semi-empirical. This is mainly due to our limited understanding of vaccination mechanism and its influencing factors. The most impo rtant factor is arguably the type and concentration of vaccine adjuvants. Until recently, however, only one type of adjuvant-aluminum salts, had been widely used within licensed human vaccines in the US, even though a variety of novel adjuvants have been evaluated in the past few decades. This review summarizes the key adjuvants that have been evaluated in recent years with an intention to facilitate more efficient development of vaccine products to combat human diseases. Keywords: Adjuvant, Alum, Aluminum Salts, Immune Response 1. Introduction cently novel methods are being developed such as re- verse vaccinology [2]. Various strategies have been in- The advent of mass vaccination significantly reduced t