the effect of aqueous extract of cecropia glazioui snethlage (embauba) in the rat fetal development水提物的效应cecropia glazioui snethlage(embauba)老鼠胎儿发育.pdfVIP

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the effect of aqueous extract of cecropia glazioui snethlage (embauba) in the rat fetal development水提物的效应cecropia glazioui snethlage(embauba)老鼠胎儿发育.pdf

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the effect of aqueous extract of cecropia glazioui snethlage (embauba) in the rat fetal development水提物的效应cecropia glazioui snethlage(embauba)老鼠胎儿发育

Chinese Medicine, 2011, 2, 115-119 doi:10.4236/cm.2011.23019 Published Online September 2011 (http://www.SciRP.org/journal/cm) The Effect of Aqueous Extract of Cecropia glazioui Snethlage (Embauba) in the Rat Fetal Development 1,2 1 1 Priscila Randazzo-Moura , Magali Glauzer Silva , Yoko Oshima-Franco , Francisco Carlos Groppo3, Marli Gerenutti1* 1School of Pharmacy, University of Sorocaba, Sorocaba, Brazil 2Pontifical Catholic University of Sorocaba, Sorocaba, Brasil 3Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil * E-mail : marli.gerenutti@prof.uniso.br Received May 15, 2011; revised May 29, 2011; accepted June 8, 2011 Abstract The effect of aqueous extract of Cecropia glazioui Snethlage (Embauba) in the rat fetal development. This study was to complement previous assays on the physical and neurobehavioral development of rats resulted from oral administration of 1 g/kg/day Cecropia glazioui Snethlage (C. glazioui) aqueous extract (LD50 5 g·kg−1) in pregnant rats (peri- and post-natal studies). In the present study, the effect of 2.5 g/kg/week C. glazioui aqueous extract, administered to pregnant rats during 15 days, was verified in the rat offspring de- velopment. No acute or chronic toxicity (no effects on mortality or weight average daily gain) were observed. In addition, no effects on reproductive parameters (offspring vitality, placenta and fetus weight, number of corpora lutea on each ovary, pre- and post-implantation loss) and on offspring external morpholo