the effect of antigen stimulation on the migration of mature t cells from the peripheral lymphoid tissues to the thymus抗原刺激的影响成熟t细胞的迁移从外围胸腺淋巴组织.pdfVIP

(C) 2001 OPA (OverseasPublishers Association) Developmental Immunology, 2001, Vol. 8(2), pp. 123-131 N.V. Published by license under Reprints available directly from the publisher the Harwood Academic Publishers imprint, Photocopying permitted by license only part of The Gordon and Breach Publishing Group, member of the Taylor and Francis Group The Effect ofAntigen Stimulation on the Migration of Mature T Cells from the Peripheral Lymphoid Tissues to the Thymus CHARLES L. , I. GODFREY and ROLAND SCOLLAY HARDY DALE From the Centenary Institute of CancerMedicine and Cell Biology, Locked Bag no 6, Newtown, NSW, Australia, 2042 Although the maturation and export of T cells from the thymus has been extensively studied, the movement of cells in the opposite direction has been less well documented. In particular, the question of whether T cells which have been activated by antigen in the periphery are more likely to return to the thymus had been raised but not clearly answered. We examined this issue by activating T cells present in the periphery with their cognate antigen, and assess- ing migration to the thymus. TCR-transgenic cells from OT-I mice(Thyl.2/), which recog- nlse the ovalbumin in the context of b were transferr