住院儿科药品说明书之外用药调查分析.docVIP

住院儿科药品说明书之外用药调查分析[摘要] 目的：调查我院住院儿科药品说明书外的用药情况，促进临床合理用药。方法：参照相关药品说明书内容，对我院2010年1~3月儿科出院的全部病历1 112份用药医嘱进行分析。结果：超药品说明书用药的病历507份，发生率为 45.59%，主要在低龄儿童中多见，表现形式主要为年龄和给药方式超范围，药物种类主要为祛痰药（26.98%）和抗菌药物（10.34%）。结论：药品说明书外用药的在住院儿科中较普遍，具有一定的客观原因，且在治疗中发挥着重要作用，但与我国现行的法律法规相违背，应引起临床的高度重视。 [关键词] 药品说明书 儿科 调查分析 [中图分类号] R969.3[文献标识码] C[文章编号] 1673-7210（2011）02（c）-113-02 Survey and analysis on a written description of the pediatric drug external use of pediatric in-patient department ZENG Xuehua, ZHOU Bingfeng (Longgang Central Hospital of Shenzhen City, Guangdong Province, Shenzhen 518116, China) [Abstract] Objective: To investigate the situation of a written description of the pediatric drug external use of pediatric in-patient department in order to promote the rational using of clinical drug. Methods: A total of 1 112 doctor’s advices from January to March 2010 were collected from the pediatric in-patient department of our hospital, which were analyzed with the contents of medicine instruction. Results: In 1 112 doctor’s advices, there were 507 (45.59%) involved drug use that went beyond the scope of medicine instruction, which was frequently seen in underage child, the problems such as age and indication were main type. Main drug kinds were expectorants (26.98%) and anti-bacterial (10.34%). Conclusion: It’s widespread for drug use that goes beyond the medicine instruction in the pediatrics, which conforms some certain objective reasons and has significant effects, but against the principle of law in our country and should be given fully attention in clinic. [Key words] Medicine instruction; Pediatrics; Survey and analysis 药品说明书是经具有一定规模人群的药物临床试验得出用药安全、有效的医疗文书，经国家认定具有法律效力，通常情况下，临床医师用药应遵循药品说明书规定的适应证和用法等。药品说明书之外用药是指药品使用的适应证、给药方式或剂量不在官方批准的说明书之内的用法、年龄或禁忌证等范围[1]。在临床实践中，会出现涉及药品没有相关适应证而患者病情需要使用该药[2]、特殊人群使用未经临床试验确认是否合适的药物而出现超药品说明书的用药情况。如盐酸氨溴索注射液说明书用于注射，然而临床也将其用于雾化祛痰治疗。为此，笔者调查了我院儿科药品说明书之外的用药情况，并进行分析，以促进临床规范合理安全用药。 1 资料与方法 对我院2010年1~3月儿科出院的全部病历1 112份用药医嘱进行调查。按患儿年龄分为3组：新