bold temporal dynamics of rat superior colliculus and lateral geniculate nucleus following short duration visual stimulation大胆的时间动态老鼠上丘和外侧膝状体核后短时间内视觉刺激.pdfVIP

BOLD Temporal Dynamics of Rat Superior Colliculus and Lateral Geniculate Nucleus following Short Duration Visual Stimulation Condon Lau1,2, Iris Y. Zhou1,2, Matthew M. Cheung1,2, Kevin C. Chan1,2, Ed X. Wu1,2,3,4* 1 Laboratory of Biomedical Imaging and Signal Processing, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China, 2 Department of Electrical and Electronic Engineering, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China, 3 Department of Anatomy, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China, 4 Department of Medicine, The University of Hong Kong, Pokfulam, Hong Kong, Special Administrative Region, China Abstract Background: The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical structures for vision. Much of our understanding of vision was obtained using invasive and small field of view (FOV) techniques. In this study, we use non-invasive, large FOV blood oxygenation level-dependent (BOLD) fMRI to measure the SC and LGN’s response temporal dynamics following short duration (1 s) visual stimulation. Methodology/Principal Findings: Experiments are performed at 7 tesla on Sprague Dawley rats stimulated in one eye with flashing light. Gradient-echo and spin-echo sequences are used to provide complementary information. An anatomical image is acquired from one rat after injection of monocrystalline iron oxide nanoparticles (MION), a blood vessel contrast agent. BOLD responses are concentrated in the contralateral SC and LGN. The SC BOLD signal measured with gradient-echo rises to 50% of maximum amplitude (PEAK) 0.260.2 s before the LGN signal (p,0.05). The LGN signal returns to 50% of PEAK 1.461.2 s before the SC signal (p,0.05). These results indicate the SC signal rises faster than the LGN signal b