cardiopulmonary bypass during cardiac surgery modulates systemic inflammation by affecting different steps of the leukocyte recruitment cascade心脏手术期间心肺旁路调节全身炎症影响白细胞招募级联的不同步骤.pdfVIP

Cardiopulmonary Bypass during Cardiac Surgery Modulates Systemic Inflammation by Affecting Different Steps of the Leukocyte Recruitment Cascade 1 1 2 3 4 5 Jan Rossaint , Christian Berger , Hugo Van Aken , Hans H. Scheld , Peter K. Zahn , Andreas Rukosujew , Alexander Zarbock6* ¨ ¨ 1 Department of Anesthesiology, Intensive Care and Pain Medicine, University Hospital Munster, Munster, Germany, 2 Department of Anesthesiology, Intensive Care and ¨ ¨ ¨ ¨ Pain Medicine, University Hospital Munster, Munster, Germany, 3 Department of Thoracic and Cardiovascular Surgery, University Hospital Munster, Munster, Germany, 4 Department of Anesthesiology, Intensive Care Medicine, Palliative Care Medicine and Pain Management, University Hospital Bergmannsheil Bochum, Bochum, Germany, ¨ ¨ 5 Department of Thoracic and Cardiovascular Surgery, University Hospital Munster, Munster, Germany, 6 Department of Anesthesiology, Intensive Care and Pain Medicine, ¨ ¨ University Hospital Munster, Munster, Germany Abstract Background: It is known that the use of a cardiopulmonary bypass (CPB) during cardiac surgery leads to leukocyte activation and may, among other causes, induce organ dysfunction due to increased leukocyte recruitment into different organs. Leukocyte extravasation occurs in a cascade-like fashion, including capturing, rolling, adhesion, and transmigration. However, the molecular mechanisms of increased l