cardiometabolic plasticity in response to a short-term diet and exercise intervention in young hispanic and nonhispanic white adults代谢疾病可塑性响应短期饮食和运动干预年轻的拉美裔和nonhispanic白色的成年人.pdfVIP

Cardiometabolic Plasticity in Response to a Short-Term Diet and Exercise Intervention in Young Hispanic and NonHispanic White Adults 1 2 2 1 1 Stacy L. Schmidt , Matthew S. Hickey , Kathryn M. Koblenz , Holly Klamer , Maria F. Botero , Kyle T. 3 3 1 Pfaffenbach , Michael J. Pagliassotti , Christopher L. Melby * 1 Nutrition and Metabolic Fitness Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, Colorado, United States of America, 2 Human Performance/Clinical Research Laboratory, Department of Health and Exercise Science, Colorado State University, Fort Collins, Colorado, United States of America, 3 Molecular Nutrition Laboratory, Department of Food Science and Human Nutrition, Colorado State University, Fort Collins, Colorado, United States of America Abstract Background: Young adult Mexican Americans (MA) exhibit lower insulin sensitivity (Si) than nonHispanic whites (NHW), even when controlling for fitness and adiposity. It is unclear if MA are as responsive to the same lifestyle intervention as NHW. Objective: We developed a model to examine cardiometabolic plasticity (i.e., changes in Si and plasma lipids) in MA compared to NHW adults in response to a diet-exercise intervention. 2 2 Design: Sedentary subjects (20 NHW: 11F, 9M, 23.0 y, 25.5 kg/m ; 17 MA: 13F, 4M, 22.7 y, 25.4 kg/m ) consumed their habitual diets and remained sedentary for 7 days, after which fasting blood samples were obtained, and a 3-h intraven