simulating radiotherapy effect in high-grade glioma by using diffusive modeling and brain atlases模拟在高档神经胶质瘤放疗效果使用扩散模型和脑图谱.pdfVIP

Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 715812, 9 pages doi:10.1155/2012/715812 Research Article Simulating Radiotherapy Effect in High-Grade Glioma by Using Diffusive Modeling and Brain Atlases Alexandros Roniotis,1, 2 Kostas Marias,1 Vangelis Sakkalis,1 Georgios C. Manikis,1 and Michalis Zervakis2 1 Institute of Computer Science, Foundation For Research and Technology-Hellas, 700 13 Heraklion, Crete, Greece 2 Department of Electronic Computer Engineering, Technical University of Crete, 73100 Chania, Greece Correspondence should be addressed to Alexandros Roniotis, roniotis@ics.forth.gr Received 21 February 2012; Revised 18 May 2012; Accepted 21 May 2012 Academic Editor: George E. Plopper Copyright © 2012 Alexandros Roniotis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Applying diffusive models for simulating the spatiotemporal change of concentration of tumour cells is a modern application of predictive oncology. Diffusive models are used for modelling glioblastoma, the most aggressive type of glioma. This paper presents the results of applying a linear quadratic model for simulating the effects of radiotherapy on an advanced diffusive glioma model. This diffusive model takes into consideration the heterogeneous velocity of glioma in gray and white matter and the anisotropic migration of tumor cells, which is facilitated along white fibers. This work uses normal brain atlases for extracting the proportions of white and gray matter and the diffusion tensors used for anisotropy. The paper also presents the results of applying this glioma