analysis of ceftriaxone-induced anaphylactic shock（分析ceftriaxone-induced过敏性休克）.docVIP

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analysis of ceftriaxone-induced anaphylactic shock（分析ceftriaxone-induced过敏性休克）.doc

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analysis of ceftriaxone-induced anaphylactic shock（分析ceftriaxone-induced过敏性休克）

Analysis of ceftriaxone-induced anaphylactic shock [Paper Keywords] ceftriaxone; anaphylactic shock; Ⅰ-type hypersensitivity [Abstract] Ceftriaxone is commonly used in clinical third-generation cephalosporin antibiotics, allergy is one of its adverse reactions, anaphylactic shock is the most serious allergic reaction, allergic constitution often occur immediately after application. Drug Some cross with penicillin allergy, so the history of penicillin allergy caution, ceftriaxone allergy. The patients had no history of allergy to penicillin, ceftriaxone skin test negative, and the continuous occurrence of drug allergy-free 3 d, the first four days of severe anaphylactic shock, clinically rare. may be impure with drugs or low molecular weight impurities and degradation products formed with the body’s proteins should change dollars, so that the body type Ⅰ allergy related sensitization occurs. colleagues in this situation deserves attention. Ceftriaxone is widely used clinically, few medication allergy allergy can be mild, such as skin rashes, allergic dermatitis, urticaria, pruritus, erythema multiforme, bronchospasm, etc. The anti-allergy treatment, symptoms can be quickly disappear. very few may be severe anaphylactic shock, often occurs in a few seconds - minutes, development and death. I had seen a patient in the clinical treatment in a continuous process in the first four days of severe anaphylactic shock with stress-induced gastrointestinal bleeding, active rescue cured. Are reported as follows: A medical records Patients, female, 44 years old. Because of abdominal pain, chills, fever 2 d treatment. 2 d before the patient outside the hospital cervical polypectomy, after the afternoon accompanied by lower abdominal pain, chills, fever, T: 37.8 ℃, at home from antibiotics (specifically unknown) 2 d, invalid, then to our hospital. admission examination: T38.2 ℃, BP112/80 mmHg, no abnormal heart and lung, abdomen flat, positive abdominal tenderness