a pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology核不稳定的试点研究存档与假定的赭曲霉素肾和上尿路肿瘤病因学.pdfVIP

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a pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology核不稳定的试点研究存档与假定的赭曲霉素肾和上尿路肿瘤病因学.pdf

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a pilot study of nuclear instability in archived renal and upper urinary tract tumours with putative ochratoxin aetiology核不稳定的试点研究存档与假定的赭曲霉素肾和上尿路肿瘤病因学

Toxins 2010, 2, 326-340; doi:10.3390/toxins2030326 OPEN ACCESS toxins ISSN 2072-6651 /journal/toxins Article A Pilot Study of Nuclear Instability in Archived Renal and Upper Urinary Tract Tumours with Putative Ochratoxin Aetiology Peter G. Mantle 1,*, Cyrille Amerasinghe 2, Amy L. Brown 3, Diana Herman 4, Thomas Horn 5, 6 3 7 8 Thoger Krogh , Edward W. Odell , Tomas Rosenbaum and Calin A. Tatu 1 Centre for Environmental Policy, Imperial College London, London SW7 2AZ, UK 2 Department of Histopathology, Ealing Hospital, Southall, Middlesex, UB1 3HW, UK 3 Department of Oral Pathology, Kings College London, London, UK 4 Pathology Department, County Hospital Timisoara, Romania 5 Pathology Department, Herlev Hospital, University of Copenhagen, DK-2730 Herlev, Denmark 6 Department of Rheumatology, Aarhus University Hospital, 8000 Aarhus. Denmark 7 Department of Urology, Ealing Hospital, Southall, Middlesex. UB1 3HW, UK 8 Department of Biology, University of Medicine and Pharmacy, Timisoara, Romania * Author to whom correspondence should be addressed; E-Mail: p.mantle@imperial.ac.uk; Tel.: +44-207-594-5245. Received: 21 January 2010; in revised form: 22 February 2010 / Accepted: 24 February 2010 / Published: 9 March 2010 Abstract: DNA ploidy measurement has been applied uniquely to wax-embedded tissue of primary renal cell and metastatic tumours of a key experimental researcher on porcine ochratoxicosis, a control, and four tra