expression of the pten gene in primary hepatocellular carcinoma（原发性肝细胞癌pten基因的表达）.docVIP

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expression of the pten gene in primary hepatocellular carcinoma（原发性肝细胞癌pten基因的表达）.doc

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expression of the pten gene in primary hepatocellular carcinoma（原发性肝细胞癌pten基因的表达）

Expression of the PTEN gene in primary hepatocellular carcinoma [Abstract] Objective To explore the role of the PTEN gene mutation in the development of hepatocellular carcinoma (HCC), Methods Semi-quantitative reverse transcriptase polymerase chain reaction (RT PCR) technology, 30 cases of HCC, 30 cases of adjacent expression of the PTEN gene in tissues and 16 cases of normal liver tissue cells to detect and analyze the results of the PTEN gene in liver cancer tissue expression level was significantly lower than the adjacent tissues and normal liver tissue (F = 6.785, q = 4.269,4.549, P lt;0.05 level of PTEN gene expression in poorly differentiated HCC tissues was significantly lower than the high, moderately differentiated HCC tissues (t = 3.266, P lt;0.01). Conclusion PTEN gene inactivation is closely related with liver cancer, PTEN gene expression level significant correlation between the degree of malignancy of HCC, suggesting that the variation can be used as indicators of patient prognosis. [Keywords:] gene PTEN RNA messenger carcinoma of liver cells by reverse transcription polymerase chain reaction [ABSTRACT] ObjectiveTo study the role of PTEN variation in the pathogenesis of hepatocellular carcinoma (HCC). MethodsSemi  quantitive reverse transcriptase polymerase chain reaction (RT PCR) was adopted to detect the expression of PTEN gene in 30 HCC and their adjacent tissues as well as 16 normal liver tissues served as controls. ResultsThe expression level of PTEN gene in the HCC tissues was significantly lower than that in the adjacent and normal liver tissues (F = 6.785; q = 4.269,4.549; P lt;0.05. In lowly differentiated HCC tissue, the expression of PTEN was much lower than that in the highly and moderately differentiated HCC tissues (t = 3.266, P lt;0.01). ConclusionThe inactivation of PTEN is closely associated with the pathogenesis of hepatocellular carcinoma, and the expression of PTEN is highly related with the malignancy of the cancer, w