expression on different time intracerebroventricular subventricular zone musashi1 after birth（表达在不同时间intracerebroventricular subventricular区musashi1出生后）.docVIP

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expression on different time intracerebroventricular subventricular zone musashi1 after birth（表达在不同时间intracerebroventricular subventricular区musashi1出生后）.doc

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expression on different time intracerebroventricular subventricular zone musashi1 after birth（表达在不同时间intracerebroventricular subventricular区musashi1出生后）

Expression on different time Intracerebroventricular subventricular zone Musashi1 after birth The: Ma Qiaoying of Tie-Jun Xu Wang Heming Wang Meishen [Keywords:] RNA binding protein; Musashi1; neural stem cells; subventricular zone; rats Abstract: Objective To observe the neuron-specific RNA binding protein Musashi1 (Msi1 in different developmental time after birth lateral ventricle subventricular zone (within the SVZ expression change. Methods Male SD rats, divided into seven days, two weeks, three weeks January, February, adult (6 months of age and older (18 months old) group, n = 5, 35, paraformaldehyde fixed, frozen coronal sections, immunohistochemistry (ABC staining, light microscope camera, cell count results seen in rats of various age groups periventricular SVZ the Msi1 immune response positive cells, small round cell body, no protrusions or 1 to 2 short protruding, uneven distribution of density; increasing age Msi1 positive cells, SVZ gradually reduced, there is still a certain amount of Msi1-positive cells in the aged rats. conclusions Intracerebroventricular SVZ memory Msi1 positive cells and age significantly reduced, these cells may be neural stem cells. Keywords:: RNA-binding protein; Musashi1; neural stem cells; subventricular zone; rats Abstract: Objective To observe the expression of neural RNA-binding proteins Musashi1 (Msi1in the subventricular zone (SVZ) of lateral ventricles (LVat different postnatal developing times.Methods Healthy male SD rats of different age groups were recruited (1 - ,2-and3 -week groups ,1-and2-month groups ,6-month grown group, and18-month aged group; n = 5each.Immunohistochemistry was performed on the coronal sections of brain of the rats perfused with paraformaldehyde.Results The expression of Msi1was observed in the SVZ of LV in all groups.Msi1-positive cells were small and round in shape, showing no or1 ~ 2short processes on the surface.The Musashi1-positive cells were unevenly dis-tributed.The num