脓毒症AKI时肾组织细胞凋亡及及TLR49通络关系的实验研究.pdf

目 录 中文摘要………………………………………………………………………l 英文摘要……………………………………………………………………·12 英文缩写……………………………………………………………………·27 研究论文 脓毒症AⅪ时肾组织细胞凋亡及与TLR4／9通路关系的实验 研究 弓l言································································．．··············29 第一部分 脓毒症AKI小鼠模型制备 OO AOOOOOOOO ““”””””””””“”“”””””””””””“_j 前言···000刖舌”。 O··········…··········…··…··············…····3。1 材料与方法……………………………………………………………·3l 结果······…····························…················…·············…····38 附图···············································································4l 附表···············································································45 讨论···················································…·························46 爿、结······························································“·····““··“··48 参考文献………………………………………………………………·49 第二部分 肾组织细胞凋亡在脓毒症铷阻小鼠中的作用及选择性 caspase．3抑制剂预防性干预的研究 前言…··…···…·······……·····…·……·…····…·…······…··…000000005—2=z 日lJ舌”””””””””“““”””””””””””””””””””““””。 材料与方法……………………………………………………………·53 结果…··…···…········………··………·…····…·……···…····…······59 附图···············································································62 附表···············································································68 讨论···············································································70 ／J、结···············································································73 参考文献………………………………………………………………·73 第三部分 制剂预防性干预的研究 OOOOOO…··OOOOo…··OOaOOo””‘ ”“。 o·ooeeo。 ooooooOOOO DOOOOO 前言…O朗舌”· O……．O”””· OOOOOOOO OOOO…·77””。7‘7 材料与方法……………………………………………………………·78 结果……·…··…·····…………·…··…·……··……··…·····……·……80 附表············