原创力文档nucleosome deposition and dna methylation at coding region boundaries核小体沉积和dna甲基化编码区边界.pdfVIP
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nucleosome deposition and dna methylation at coding region boundaries核小体沉积和dna甲基化编码区边界
Volume 10, Issue 9, Article R89et al.Choi2009 Open Access
Research
Nucleosome deposition and DNA methylation at coding region
boundaries
* * * †
Jung Kyoon Choi , Jae-Bum Bae , Jaemyun Lyu , Tae-Yoon Kim and
Young-Joon Kim*
Addresses: *Department of Biochemistry, College of Life Science and Technology, Yonsei University, 134 Sinchon-dong, Seodaemun-gu, Seoul,
Korea. †Laboratory of Dermato-Immunology, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, Korea.
Correspondence: Young-Joon Kim. Email: yjkim@yonsei.ac.kr
Published: 1 September 2009 Received: 24 June 2009
Revised: 10 August 2009
Genome Biology 2009, 10:R89 (doi:10.1186/gb-2009-10-9-r89)
Accepted: 1 September 2009
The electronic version of this article is the complete one and can be
found online at /2009/10/9/R89
© 2009 Choi et al.; licensee BioMed Central Ltd.
This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which
permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Epigenetics at ends of coding regionspNucleosomes and methylation have been observed to peak at both ends of protein coding units in a genome-wide survey./p
Abstract
Background: Nucleosome deposition downstream of transcription initiation and DNA
methylation in the gene body suggest that control of transcription elongation is a key aspect of
epigenetic reg
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