原创力文档numerical and experimental study on the development of electric sensor as for measurement of red blood cell deformability in microchannels数值和实验研究的发展,电动传感器作为测量的红细胞可变形性巩膜.pdfVIP
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numerical and experimental study on the development of electric sensor as for measurement of red blood cell deformability in microchannels数值和实验研究的发展,电动传感器作为测量的红细胞可变形性巩膜
Sensors 2012, 12, 10566-10583; doi:10.3390/s120810566
OPEN ACCESS
sensors
ISSN 1424-8220
/journal/sensors
Article
Numerical and Experimental Study on the Development of
Electric Sensor as for Measurement of Red Blood Cell
Deformability in Microchannels
Kazuya Tatsumi *, Yoichi Katsumoto, Ryoji Fujiwara and Kazuyoshi Nakabe
Department of Mechanical Engineering and Science, Kyoto University, Sakyo-ku, Kyoto 606-8501,
Japan; E-Mails: yoichi.katsumoto@fy7.ecs.kyoto-u.ac.jp (Y.K.);
ryouji.fujiwara@t06.mbox.media.kyoto-u.ac.jp (R.F.); nakabe@me.kyoto-u.ac.jp (K.N.)
* Author to whom correspondence should be addressed; E-Mail: tatsumi@me.kyoto-u.ac.jp;
Tel.: +81-75-753-5224; Fax: +81-75-753-5209.
Received: 10 May 2012; in revised form: 18 July 2012 / Accepted: 25 July 2012 /
Published: 3 August 2012
Abstract: A microsensor that can continuously measure the deformability of a single red
blood cell (RBC) in its microchannels using microelectrodes is described in this paper. The
time series of the electric resistance is measured using an AC current vs. voltage method as
the RBC passes between counter-electrode-type micro-membrane sensors attached to the
bottom wall of the microchannel. The RBC is deformed by the shear flow created in the
microchannel; the degree of deformation depends on the elastic modulus of the RBC. The
resistance distribution, which is unique to the shape of the RBC, is analyzed to obtain the
deformability of each cell. First, a numerical simulation of the electric field around the
e
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