numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores数字计算需要治疗的应答率给更好的指示效果比平均疼痛评分骨关节炎试验.pdfVIP

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numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores数字计算需要治疗的应答率给更好的指示效果比平均疼痛评分骨关节炎试验.pdf

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numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores数字计算需要治疗的应答率给更好的指示效果比平均疼痛评分骨关节炎试验

Available online /content/10/2/R39 Vol 10 No 2 Open Access Research article Numbers needed to treat calculated from responder rates give a better indication of efficacy in osteoarthritis trials than mean pain scores 1 2 1 1 R Andrew Moore , Owen A Moore , Sheena Derry and Henry J McQuay 1Pain Research and Nuffield Department of Anaesthetics, University of Oxford, Oxford Radcliffe Hospital, Oxford OX3 7LJ, UK 2Department of Rheumatology, Musgrove Park Hospital, Stockmans Lane, Belfast BT0 7JB, UK Corresponding author: R Andrew Moore, andrew.moore@pru.ox.ac.uk Received: 6 Feb 2008 Revisions requested: 14 Mar 2008 Revisions received: 27 Mar 2008 Accepted: 2 Apr 2008 Published: 2 Apr 2008 Arthritis Research Therapy 2008, 10:R39 (doi:10.1186/ar2394) This article is online at: /content/10/2/R39 © 2008 Moore et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Osteoarthritis trials usually report average Results With placebo, the proportions of patients achieving at changes in visual analogue scale (VAS) pain, and examine the least 20%, 50% and 70% pain relief over baseline at 6 weeks difference between treatment and placebo. We investigated were 30%, 11% and 2%. With 60 mg etoricoxib the equivalent whether dichotomous responder analysis provides a more percentages were 74%, 49% and 29%. The numbers n