preparation of silver- and zinc-doped mullite-based ceramics showing anti-bacterial biofilm properties制备的银,zinc-doped mullite-based陶瓷显示抗菌生物膜特性.pdfVIP

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preparation of silver- and zinc-doped mullite-based ceramics showing anti-bacterial biofilm properties制备的银,zinc-doped mullite-based陶瓷显示抗菌生物膜特性.pdf

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preparation of silver- and zinc-doped mullite-based ceramics showing anti-bacterial biofilm properties制备的银,zinc-doped mullite-based陶瓷显示抗菌生物膜特性

Molecules 2011, 16, 2862-2870; doi:10.3390/molecule OPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Preparation of Silver- and Zinc-Doped Mullite-Based Ceramics Showing Anti-Bacterial Biofilm Properties 1 2 3 2 Suhair Saleh , Mutasem O. Taha , Randa N. Haddadin , Duá Marzooqa and Hamdallah Hodali 4,* 1 Department of Pharmaceutical Sciences and Pharmaceutics, Applied Science University, Amman, Jordan 2 Drug Discovery Unit, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Jordan, Amman, Jordan 3 Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Jordan, Amman, Jordan 4 Department of Chemistry, Faculty of Sciences, University of Jordan, Amman, Jordan * Author to whom correspondence should be addressed; E-Mail: h-hodali@.jo; Tel.: +962-776-717-080. Received: 18 February 2011; in revised form: 21 March 2011 / Accepted: 28 March 2011 / Published: 31 March 2011 Abstract: Zinc- and silver-doped mullite ceramic discs were prepared and tested as potentially resistant materials against bacterial adhesion and biofilm formation. Elemental analysis and X-ray diffraction studies showed that zinc ions were incorporated in the structural framework of the mullite, while silver ions remained outside the mullite crystal lattice, which allowed their slow (0.02 ppm/24 hours) leaching into the surrounding aqueous envi