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s100a8 and s100a9 in experimental osteoarthritiss100a8和s100a9实验性骨关节炎
Zreiqat et al. Arthritis Research Therapy 2010, 12:R16
/content/12/1/R16
RESEARCH ARTICLE Open Access
S100A8 and S100A9 in experimental
osteoarthritis
1*† 2† 3 2 2 1
Hala Zreiqat , Daniele Belluoccio , Margaret M Smith , Richard Wilson , Lynn A Rowley , Katie Jones ,
1 4 4 2 3
Yogambha Ramaswamy , Thomas Vogl , Johannes Roth , John F Bateman , Christopher B Little
Abstract
Introduction: The objective was to evaluate the changes in S100A8 S100A9, and their complex (S100A8/S100A9)
in cartilage during the onset of osteoarthritis (OA) as opposed to inflammatory arthritis.
Methods: S100A8 and S100A9 protein localization were determined in antigen-induced inflammatory arthritis in
mice, mouse femoral head cartilage explants stimulated with interleukin-1 (IL-1), and in surgically-induced OA in
mice. Microarray expression profiling of all S100 proteins in cartilage was evaluated at different times after initiation
of degradation in femoral head explant cultures stimulated with IL-1 and surgically-induced OA. The effect of
S100A8, S100A9 or the complex on the expression of aggrecan (Acan), collagen II (Col2a1), disintegrin and
metalloproteases with thrombospondin motifs (Adamts1, Adamts 4 Adamts 5), matrix metalloproteases (Mmp1,
Mmp3, Mmp13 Mmp14) and tissue inhibitors of metalloproteinases (Timp1, Timp2 Timp3), by primary adult ovine
articular chondrocytes was determined using real time quantitative reverse transcription polymerase chain reaction
(qRT-PCR).
Results: Stimulation with IL-1 increased chondrocyte S100a8 and S100a9 mRNA and protein levels. There was
increased chondrocyte mRN
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