原创力文档safety profile of l-arginine infusion in moderately severe falciparum malaria安全性精氨酸注入在中等严重的恶性疟疾.pdfVIP
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safety profile of l-arginine infusion in moderately severe falciparum malaria安全性精氨酸注入在中等严重的恶性疟疾
Safety Profile of L-Arginine Infusion in Moderately
Severe Falciparum Malaria
1 2 3 3 2
Tsin W. Yeo , Daniel A. Lampah , Retno Gitawati , Emiliana Tjitra , Enny Kenangalem , Donald L.
4 5 4 1,6,7 8
Granger , J. Brice Weinberg , Bert K. Lopansri , Ric N. Price , David S. Celermajer , Stephen B.
Duffull9, Nicholas M. Anstey1,6*
1 International Health Division, Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia, 2 Menzies School of Health Research-
National Institute of Health Research and Development Research Program, and District Ministry of Health, Timika, Papua, Indonesia, 3 National Institute of Health Research
and Development, Jakarta, Indonesia, 4 Division of Infectious Diseases, VA Medical Centers, University of Utah, Salt Lake City, Utah, United States of America, 5 Division of
Hematology-Oncology, VA Medical Centers, Duke University School of Medicine, Durham, North Carolina, United States of America, 6 Division of Medicine, Royal Darwin
Hospital, Darwin, Northern Territory, Australia, 7 Centre for Vaccinology and Tropical Medicine, Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Oxford,
United Kingdom, 8 Department of Medicine, University of Sydney and Department of Cardiology, Royal Prince Alfred Hospital, Sydney, Australia, 9 School of Pharmacy,
University of Otago, Dunedin, New Zealand
Abstract
Background: L-arginine infusion improves endothelial function in malaria but its safety profile has not been described in
detail. We assessed clinical symptoms, hemodynamic status and biochemical parameters before and after a single L-arginine
infusion in adults with
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