原创力文档the anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment的anti-cyclic citrullinated肽反应对治疗肺结核病人不是citrulline-dependent和敏感.pdfVIP
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the anti-cyclic citrullinated peptide response in tuberculosis patients is not citrulline-dependent and sensitive to treatment的anti-cyclic citrullinated肽反应对治疗肺结核病人不是citrulline-dependent和敏感
Elkayam et al. Arthritis Research Therapy 2010, 12:R12
/content/12/1/R12
R E S E A R C H A R T I C L E Open Access
Research article
The anti-cyclic citrullinated peptide response in
tuberculosis patients is not citrulline-dependent
and sensitive to treatment
†1 †2 3 4 5 5
Ori Elkayam* , Refael Segal , Daniele Bendayan , Robert van Uitert , Carla Onnekink and Ger JM Pruijn
Abstract
Introduction: Patients with tuberculosis (TB) frequently produce anti-citrullinated protein antibodies (ACPA). The
objective of this study is to characterize the citrulline-dependence of the ACPA reactivity in sera of patients with
mycobacterium infections.
Methods: Serum samples of 134 patients with untreated mycobacterium infections (122 TB, 12 nontuberculous
mycobacterium) were tested for antibodies against both the citrullinated (Cit) and the non-citrullinated (Arg) form of 2
cyclic synthetic peptides. In 33 patients, a follow-up sample was tested six months after starting anti-mycobacterial
drugs.
Results: A substantial proportion of patients with mycobacterial infections demonstrated antibodies against 0401Cit,
0401Arg, 0722Cit and 0722Arg. Fourteen patients demonstrated anti-0401Cit, 83 anti-0401Arg, 22 anti-0722Cit and 61
anti-0722Arg, while none of these antibodies were detected in the 20 healthy controls. All the patients but one, who
were anti-0401Cit and anti-0722Cit positive, demonstrated reactivity against the respective Arg peptide. In the subset
of 33 patients with a follow-up test six months after starting treatment, the mean levels of antibodies to 0401Cit,
0401Arg, 0722Cit and 0722Arg significantly decreased after treatment. All the patients who were anti-0401Cit and anti-
0722Cit positive turn
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