what leads indians to participate in clinical trials a meta-analysis of qualitative studies什么导致印度人参与临床试验的荟萃分析定性研究.pdfVIP

What Leads Indians to Participate in Clinical Trials? A Meta-Analysis of Qualitative Studies Jatin Y. Shah1,2, Amruta Phadtare2,3, Dimple Rajgor 1,2, Meenakshi Vaghasia2,3, Shreyasee Pradhan1,2, Hilary Zelko2,4, Ricardo Pietrobon1,2,4* 1 Graduate Medical School, Duke-National University of Singapore, Singapore, Singapore, 2 Research on Research Group, Duke University, Durham, North Carolina, United States of America, 3 Kalpavriksha Healthcare and Research, Thane, India, 4 Department of Surgery, Duke University, Durham, North Carolina, United States of America Abstract Background: With the globalization of clinical trials, large developing nations have substantially increased their participation in multi-site studies. This participation has raised ethical concerns, among them the fear that local customs, habits and culture are not respected while asking potential participants to take part in study. This knowledge gap is particularly noticeable among Indian subjects, since despite the large number of participants, little is known regarding what factors affect their willingness to participate in clinical trials. Methods: We conducted a meta-analysis of all studies evaluating the factors and barriers, from the perspective of potential Indian participants, contributing to their participation in clinical trials. We searched both international as well as Indian- specific bibliographic databases, including Pubmed, Cochrane, Openjgate, MedInd, Scirus and Medknow, also performing hand searches and communicating with authors to obtain additional references. We enrolled studies dealing exclusively with the participation of Indians in clinical trials. Data extraction was conducted by three researchers, with disagreement being resolved by consensus. Results: Six qualitative studies and one survey were found evaluating the mai