全球抗肿瘤药物研发报告2015-药学进展.pdfVIP

PROGRESS IN PHARMACEUTICAL SCIENCES 2015,39 3 :227-234 ( ) 227 ·热点透视· H O T S P O T S P E R S P E C T I V E 全球抗肿瘤药物研发报告（2015） 吴慧，高柳滨* ( 中国科学院上海药物研究所 , 上海 201203) [ 摘要 ] 全球癌症发病形势严峻，发病率与死亡率呈持续上升趋势。近年来抗肿瘤创新药物的激增以及研发进程的强劲表现持续推动抗肿瘤 药物市场的快速发展。报告采用文献调研、数据库检索、数据统计与分析等定性定量情报研究方法，从药物数量、研发阶段、研发公司、 适应证、作用机制、技术类型、销售情况等角度对全球抗肿瘤药物的研发情况进行多角度、多层次的分析，旨在为我国抗肿瘤药物的研发 提供参考。 [ 关键词 ] 肿瘤；药物研发；靶点；研发机构 [ 中图分类号 ] R979.1 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2015）03-0227-08 eport on Global Development of Antitumor Drugs (2015) R WU Hui, GAO Liubin (Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China) [Abstract] The global situation of cancer is grim with continuous rise in the incidence and mortality in recent years. The surge of innovative anti- cancer drugs as well as exciting breakthroughs in RD process have continued to promote the rapid development of anti-cancer drugs market. Base on qualitative and quantitative information research methods including literature research, database retrieval as well as data statistics and analysis, the global antitumor drugs research was analyzed in this report from various aspects of drug number, development stage, developer, indication, mechanism, technology and sale in the hope of providing useful data and reference for researchers. [Key words] tumor; drug research and development; drug target; RD institution 现今，肿瘤已经成为一种严重威胁人类健康的常见 据中国肿瘤登记中心发布的《2013 年中国肿瘤登记年 疾病。据世界卫生组织（WHO）发布的《2014 年全球 报》显示，我国肿瘤的发病率和死亡率逐年增加，恶 癌症报告》称，2012 年全球新增约 1 400 万例癌症病例， 性肿瘤疾病中发病率最高的是肺癌，中国每年新增肺 预计 2025 年全球新增癌症病例数约为 1 900 万，2035 年 癌病例数高达 60 万。 将