钙网蛋白与肿瘤免疫.pdf

第23卷第10期 生命科学 Vol. 23, No. 10 2011年10月 Chinese Bulletin of Life Sciences Oct., 2011 文章编号：1004-0374(2011) 10-1009-05 钙网蛋白与肿瘤免疫 吴红艳，王艳林* 443002 (三峡大学分子生物学研究所，宜昌 ； 武汉大学中南医院肿瘤科，武汉 430072) 摘　要：钙网蛋白是内质网分子伴侣，负责糖蛋白的折叠及维持细胞内Ca2+ 平衡。新近研究发现，某些凋 亡刺激能诱导肿瘤细胞内的钙网蛋白快速转位到肿瘤细胞膜上，这种表面包被有大量钙网蛋白的肿瘤细胞， 能被抗原呈递细胞有效识别和吞噬，由此激发抗同种肿瘤的特异性免疫杀伤效应，提示钙网蛋白在肿瘤免 疫治疗中的潜在应用价值。对钙网蛋白在肿瘤免疫中的研究进展作一综述。 关键词：钙网蛋白；内质网应激 ；免疫原性细胞死亡 ；肿瘤免疫 R730.51 A 中图分类号： 文献标识码 ： Calreticulin and tumor immunity WU Hong-Yan, WANG Yan-Lin* (Institute of Molecular Biology, Three Gorges University, Yichang 443002, China; Department of Oncology, Zhongnan Hospital, Wuhan University, Wuhan 430072, China) Abstract: Calreticulin (CRT) is an endoplasmic reticulum (ER) chaperone responsible for glycoprotein folding and Ca2+ homeostasis. Recent researches showed that some apoptotic stimulus could trigger relocation of intracellular CRT onto the tumor cell surfaces. These CRT-coated tumor cells could be recognized and phagocytosed by antigen presenting cells efficiently, and elicited specific anti-tumor immune response against homologous tumor cells, indicating the potential value of CRT in tumor immune therapy. Here, we summarize the research progress of CRT in tumor immunity. Key words: calreticulin; endoplasmic reticulum stress; immunogenic cell death; tumor immunity 1254 bp 417 内质网是蛋白质折叠、组装以及细胞内钙离子 性阅读框架长度为