芍甘口服液提取、精制工艺设计.docVIP

目录 设计任务书·············································4 概述····················································5 1.1芍甘汤·············································5 1.2芍药···············································5 1.3甘草···············································5 1.4配伍···············································5 常用精制技术简介········································6 2.1醇沉法·············································6 2.2膜分离法···········································6 2.2.1微滤··········································6 2.2.2超滤··········································6 2.3高速离心法·········································6 2.4澄清剂吸附法·······································6 2.5大孔树脂法·········································7 课程实验···············································8 3.1处方···············································8 3.2制法···············································8 3.3数据···············································8 3.3.1固含物········································8 3.3.2高效液相······································9 3.4口服液第二组数据··································10 3.4.1固含物·······································10 3.4.2高效液相·····································10 工艺流程及分析·········································12 5.总结················································14 参考文献·················································14 设计任务书 1.设计题目 芍甘汤提取、精制工艺设计 2.设计条件 芍甘口服液提取物的工艺设计 3.设计内容与要求 （1）确定提取工艺及参数； （2）确定精制分离工艺及参数； （3）提取物得率、成分含量以及相对密度； （5）编写设计说明书； 4.设计成果 （1）设计说明书一份 包括概述（简要说明所设计的复方中药效物质成分类型、性质及药理作用等）；常用精制分离技术简述（主要为醇沉、微滤）课程实验（不同精制方法的效果及比较）；工艺线路的设计（从最终制剂的剂型、工艺合理性以及生产成本等方面考虑）。 （2）芍甘汤提取精制工艺流程图； 5.设计时间 设计时间为2周，从2015年6月8日至2015年6月19日。 1.概述 1.1芍甘汤 芍甘口服液设计来源于芍甘汤，芍甘汤全称芍药甘草汤，来源于《伤寒论》。用法：12g芍药和12g甘草加水煎煮两次，合并煎液，分两次服用，早晚各一次。功用：调和肝脾，缓急止痛，主治津液受损，阴血不足，筋脉失濡所致诸证，如伤寒伤阴、筋脉失濡、腿脚挛急等。 方中芍药酸寒，养血敛阴，柔肝止痛；甘草甘温，健脾益气，缓急止痛。二药相伍，酸甘化阴，调和肝脾，有柔筋止痛之效。 1.2芍药 方中所用芍药为赤芍。赤芍为毛茛科植物芍药 或川赤芍的干燥根。其味苦，性微寒，归肝经，具有清热凉血、散瘀镇痛之功效【1】。赤芍包含萜类及其苷、黄酮类及其苷、挥发油类等多种化学成分，具有保肝、抗肿瘤、神经保护、心脏保护、抗血栓、抗氧化、抗内毒素等多