乙酰半胱氨酸对乙肝肝硬化失代偿期的患者临床观察.docVIP

精品论文 参考文献 乙酰半胱氨酸对乙肝肝硬化失代偿期的患者临床观察 海南省人民医院 海南省 570311 摘要：目的 观察乙酰半胱氨酸对乙肝肝硬化失代偿期患者的临床效果。方法：回顾了 2015年3月～ 2016年4月在我院住院治疗的诊断并治疗的乙肝肝硬化失代偿患者122例的临床资料，随机划分为对照组及治疗组61例。对照组进行异甘草酸镁降酶、腺苷蛋氨酸退黄、维生素K1补充凝血因子等措施。治疗组较对照组加用0.9%生理盐水250ml+乙酰半胱氨酸4.0 Bid静点，连续10天。观察患者血清胆红素、凝血酶原及谷丙转氨酶水平。结果： 在血清胆红素、凝血酶原及谷丙转氨酶改善方面，治疗组及对照组治疗前后均有效（P lt;0.05）； 治疗后治疗组较对照组改善更明显（P lt;0.05）有显著统计学差异。结论：乙酰半胱氨酸对乙肝肝硬化失代偿期患者血清胆红素、凝血酶原及转氨酶的改善更有效。 关键词：肝硬化 乙酰半胱氨酸 胆红素 凝血酶原 谷丙转氨酶 【中图分类号】R521.1【文献标识码】A【文章编号】1001-5213(2016)08-0448-01 The observation of clinical effectiveness to treat hepatitis b cirrhosis of the liver decompensation period by using N-acetylcysteine Ming jun bai Xiang yang Han Department of Gastroenterology，Hainan provincial Peoplersquo;S Hospital，570311 【Abstract】Objective To investigate whether N-acetylcysteine would improve outcome in patients with hepatitis b cirrhosis of the liver decompensation period.Methods A retrospective analysis of the clinical data of 122 cases of hepatitis b cirrhosis of the liver decompensation period in 2015 March to 2016 April r in our hospital diagnosis and treatment, were randomly divided into 61 cases in the control group, N-acetylcystei group p of 61 cases. The control group were reduce enzyme by using Glycyrrhizic acid magnesium and fade jaundice by using Adenosine methionine，as well as Supplement clotting factors by vitamin K1 and other measures. N-acetylcysteine group received N-acetylcysteine intravenous infusion(4.0g，twice daily) therapy for 10consecutive days and the control group was not.we observed the clinical effect and patients with peripheral blood Serum bilirubin, and prothrombin and Alanine aminotransferase level. Results In the improvement of serum bilirubin, and prothrombin and Alt The treatment group and control group before and after treatment are effective The treatment group after treatment improve even more obvious than the control group after treatment, peripheral blood of serum bilirubin, and prothrombin and Alanine aminotransferase of tw