子痫前期患者外周血协同刺激分子CD28CTLA-4的表达研究.docVIP

精品论文 参考文献 子痫前期患者外周血协同刺激分子CD28CTLA-4的表达研究 刘萍1 沈文广2 　　1山东省青州妇幼保健院妇产科 262500；2山东省青州市人民医院 262500 　　摘要：目的 研究子痫前期患者外周血协同刺激分子CD28、CTLA-4、CD28/CTLA-4的表达，探讨子痫前期的发病机制。方法 选取2010年1月至2013年1月，在我院妇产科住院治疗的78例患者作为研究对象，其中子痫前期患者46例，正常孕妇32例。检测CD28和CTLA-4的表达。结果 子痫前期的患者CD28在CD3+CD4+T细胞和CD3+CD8+T细胞上的表达低于正常孕妇组，两者比较有差异，有统计学意义，Plt;0.05；子痫前期的患者CTLA-4在CD3+CD4+T细胞和CD3+CD8+T细胞上的表达高于正常孕妇组，两者比较有差异，有统计学意义，Plt;0.05；子痫前期的患者的CD28/CTLA-4在CD3+CD4+T细胞和CD3+CD8+T细胞上的表达低于正常孕妇组，有差异，有统计学意义，Plt;0.05。结论CD28/CTLA-4不平衡出现，导致妊娠女性出现子痫前期。 　　关键词：子痫前期；白细胞分化抗原28；细胞毒性T淋巴细胞相关抗原 　　of preeclampsia patients was studied. Then the pathogenesis of preeclampsia was investigated.Methods 78 patients were treated in our hospital from January 2010 to January 2013 as the research objects.One group was the 46 cases of patients with preeclampsia，the other group was 32 normal pregnant women. Expression of CD28 and CTLA-4 was detected.Result Expression of CD28 in preeclampsia patients CD3+CD4+T cells and CD3+CD8+T cells was lower than that in normal pregnant women group. The comparison between the two group was different，there was statistically significant and P value was less than 0.05. Expression of CTLA-4 in preeclampsia patients CD3+CD4+T cells and CD3+CD8+T cells was higher than that in normal pregnant women group. The comparison between the two group was different，there was statistically significant and P value was less than 0.05. Expression of CD28/CTLA-4 in preeclampsia patients CD3+CD4+T cells and CD3+CD8+T cells was lower than that in normal pregnant women group. The comparison between the two group was different，there was statistically significant and P value was less than 0.05.Conclusion Imbalance of CD28/CTLA-4 causes preeclampsia. 　　Keyword：Preeclampsia；Cluster of differentiation 28；Cytotoxic T lymphocyte antigen 4 　　子痫前期是妊娠期高血压疾病的五类疾病中的一种，欧美国家的人群发病率为6%—10%，在我国的人群发病率为5.6%—9.4%[1]，由于该病较早发生多器官功能的损害，对母婴具有很大的损害，孕产妇每年大约有6万人死于该病，该病成为最常见的孕产妇死因[2]。目前该病发病机理尚存在争议，免疫耐受失衡是比较受认可的病理变化的启动因素。协同刺激分子在维持免疫系统平衡方面其重要作用。CD28是最基本的协同刺激因子，CTLA-