2型糖尿病与骨质疏松症的相关性研究.docVIP

精品论文 参考文献 2型糖尿病与骨质疏松症的相关性研究 周广举 　　川北医学院附属医院内分泌科四川南充637000 　　【摘要】目的：探讨2型糖尿病与骨质疏松症的相关性研究的临床观察意义。方法：选自2010年1月~2012年6月在我科住院的54例2型糖尿病患者进行骨密度测定及糖化血红蛋白检测，并根据1年内数次糖化血红蛋白的平均值，分为控制较好组（糖化血红蛋白le;6%）和控制较差组（糖化血红蛋白﹥6%），结合病程等相关因素进行分析。结果：54例2型糖尿病患者骨密度降低39例（722%）,其中女性患病率为864%。1年内糖化血红蛋白平均高于正常水平，骨密度降低者血糖水平更高，两组有显著差异（P＜001）。结论：2型糖尿病发生骨质疏松的患病率明显高于正常人群，以女性显著，病程在9年以上者明显。骨密度降低与糖化血红蛋白水平过高密切相关。 　　【关键词】糖尿病；骨质疏松；相关性研究Type 2 diabetes and osteoporosis correlation studies 　　Zhou Guangju（North sichuan medical college affiliated hospital endocrine department.Sichuan nanchong 637000） 　　【Abstract】Objective:To study the relationship of type 2 diabetes and osteoporosis,and clinical significance.Methods:54 cases of patients with type 2 diabetes on bone mineral density measurement and detection of glycosylated hemoglobin and glycosylated hemoglobin several times within 1 year based on the average,divided into good control group6%or less(glycated hemoglobin)control and poor groups(glycated hemoglobin st13 of 6%),combined with the course of the disease and related factors were analyzed.Results:54 cases of type 2diabetes patients,39 cases(722%)of the loss of female prevalence was864%.Glycosylated hemoglobin within 1 year,on average,higher than normal levels,bone mineral density decreased blood glucose levels,higher in the two groups had significant difference(P＜001).Conclusion:type 2 diabetes significantly higher than that of normal population,the prevalence of osteoporosis in women significantly,the course of the disease in more than9years is obvious.Bone mineral density lower and high glycosylated hemoglobin levels are closely related. 　　【Key words】Diabetes;Osteoporosis;Association study 　　【中图分类号】R5871【文献标识码】B【文章编号】1674-8999(2013)08-0214-02 　　 　　1资料与方法 　　11临床资料:2型糖尿病组:2010年1月~2012年6月在我科住院的2型糖尿病患者54例(均是按1997年美国糖尿病学会关于分型及诊断标准［1］进行诊断的),其中男26例,女28例;年龄:32～90岁,平均年龄602plusmn;147岁,病程:1~25年,平均81plusmn;44年。患者检查结果显示均无不良病史，如患者长期卧床或者无酮症酸中毒，没有甲亢，心脏病，肾病急呼吸哮喘等病，否认激素类和维生素D3及钙剂用药史。与2型糖尿病组年龄﹑性别相匹配的健康体检者68例,其中男34例