酶法转化DLATC生产L半胱氨酸.pdfVIP

酶法转化DL—ATC生产L一半胱氨酸 吕国英，王普+，梅建凤 (浙江工业大学生物制药研究所，浙江杭州310014) 摘要：目的介绍酶法转化DL—ATC生产L-半胱氨酸的微生物代谢途径、生物转化反应涉及的酶的种类及特性，以 及酶法转化生产工艺。方法分析国内外有关文献资料，综述L-半胱氨酸的用途及国内外研究现状。结果与结论酶 法转化DL—ATC生产L一半胱氨酸工艺为环境友好的绿色合成工艺。固定化细胞转化技术和基因工程的发展使酶法 转化DL—ATC生产L一半胱氨酸工艺具有很好的应用开发前景。 关键词：DL—ATC：L-半胱氨酸；酶法转化 中图分类号：絮3 文献标识码：6 Productionof from DL·-ATC Conversion L--cysteine Enzymatic by LV Pu+，MEI Guo-ying，WANG Jian—feng of (Institute Biopharmaceutical University ErIgineering．ZhejiangofTechnology, Hangzhou 310014) Zhejiang ABSTRACT：OB难CrⅣET0introducethe metabolicand involvedinthe pathway enzymes progress ofthe conversionDL-J虹℃to Tb enzyme settleand conclusion to L-cysteine．～匝THODget according the relevantdomestic andinteNational literature．andcombinewith血e and nowadaysproduction of andCONCLUSIONThe conversionfrom requirement DL-ATCto L-cysteine．RESUITS enzyme isa for immobilized L-cysteinegreen environment,and and technology technology geneengineering will more forthismethod． bring vi