急性脑梗死患者纤维蛋白原功能与自由基SOD、MDA的临床研究.docVIP

精品论文 参考文献 急性脑梗死患者纤维蛋白原功能与自由基SOD、MDA的临床研究 (1柳州市柳铁中心医院神经内科 广西 柳州 545007) (2柳州市柳铁中心医院血液科 广西 柳州 545007) (3柳州市柳铁中心医院老年病科 广西 柳州 545007) (4柳州市柳铁中心医院检验科 广西 柳州 545007) 摘要】 目的：探讨纤维蛋白原功能(fibrinogen function Anticoagulant,Fg) 、自由基SOD和MDA在急性脑梗死发病中的作用。方法：按CCS评分将100例急性缺血性脑卒中病人分为轻型组、中型组和重型组，并设立对照组100名，分别采用双抗体夹心ELISA法、黄嘌呤氧化法和比色法动态测定脑梗死组及对照组发病后或入组后第1天、10天外周血浆Fg和SOD、MDA水平，分析其关系。结果：脑梗死组各时间点血浆Fg的水平明显高于正常对照组(Plt;0.01)；脑梗死组发病第1天，SOD水平明显低于对照组，MDA水平明显高于对照组(Plt;0.01)，在10天，两组比较无显著性差异；急性脑梗死患者血浆Fg水平在发病第1、10天随着病情严重程度而升高，三组比较有显著性差异(Plt;0.01)，而SOD和MDA水平只在发病第1天才与病情严重程度有变化(Plt;0.01)。结论：Fg、MDA和SOD共同参与脑梗死急性期血管病理损伤过程，Fg可作为评估急性脑梗死患者病情轻重和预后的客观指标。 【关键词】 急性脑梗死；纤维蛋白原功能；超过氧化物歧化酶；丙二醛 【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2015）35-0114-02 A Clinical Study on Acute cerebral infarction fibrinogen function and Free Radicals SOD, MDA He jianming1, Zhu Mingxia2, Xu hong3, Yang dongyi3, Wei liumei4（1.Department of Neurology, 2 .Department of Hematology, 3.Department of Geriatrics, 4.Department of Clinical Laboratory, Liu Liuzhou Railway Central Hospital, Liu Zhu Guang XiI China. 545007） 【Abstract】Objective To investigate the function of fibrinogen (fibrinogen function Anticoagulant, Fg), Free Radicals SOD and MDA in the role of free radicals in the pathogenesis of acute cerebral infarction.Methods Press CCS score of 100 patients with acute ischemic stroke patients group divided into light, medium group and severe group, and a control group 100, respectively, by double antibody sandwich ELISA method, a xanthine oxidase method and the colorimetric determination of brain dynamics infarction group and control group on day 1, 10 days after the onset of or into the peripheral blood plasma Fg and SOD, MDA level, analyze their relationships.. Results Fg plasma levels of cerebral infarction at each time point were significantly higher than the control group (Plt;0.01); the first day of the onset of cerebral infarction group, SOD levels were significantly lower than the contr