新生儿胆红素脑病患儿应用换血疗法治疗的意义探析.docVIP

精品论文 参考文献 新生儿胆红素脑病患儿应用换血疗法治疗的意义探析 南华大学附属郴州市第一人民医院 423000 【摘 要】目的：研究新生儿胆红素脑病患儿应用换血疗法治疗的意义。方法：选择来自我院2012年2月-2015年12月新生儿胆红素脑病患儿100例。100例新生儿胆红素脑病患儿随机分为常规组和换血组。常规组未采用换血疗法，换血组应用换血疗法治疗。比较两组患儿并发症发生率；住院天数；治疗前和治疗后患儿总胆红素、间接胆红素、血红蛋白的差异。结果：两组败血症、坏死性小肠结肠炎、听力损害、脑损害等并发症发生率无显著差异，P＞0.05；换血组电解质紊乱、窦性心动过缓发生率则明显高于常规组，P＜0.05；换血组相较于常规组住院天数更短，P＜0.05；治疗前两组总胆红素、间接胆红素、血红蛋白相似，P＞0.05；治疗后两组患儿总胆红素、间接胆红素均显著降低，P＜0.05，但组间差异不显著，P＞0.05。而换血组血红蛋白明显提高，常规组却无明显变化，P＜0.05。结论：新生儿胆红素脑病患儿应用换血疗法治疗可一定程度上降低胆红素水平，纠正贫血状态，但易引发电解质紊乱等不良事件的发生，且无法降低听力和脑损害。 【关键词】新生儿胆红素脑病患儿；换血疗法；治疗效果 [Abstract] Objective：To study the neonatal bilirubin encephalopathy in children with blood transfusion therapy in the treatment of meaning. Methods：100 cases of neonatal bilirubin encephalopathy in our hospital from February 2012 December to were selected. 100 cases of neonatal bilirubin encephalopathy were randomly divided into routine group and blood group. The conventional group did not use blood transfusion therapy，blood transfusion group exchange transfusion therapy in treatment. The incidence of complications was compared between the two groups；the length of hospital stay；the difference of total bilirubin，indirect bilirubin and hemoglobin in the patients before and after treatment. Results：two cases of sepsis and necrotizing enterocolitis，hearing loss，brain damage and other complications had no significant difference，P gt; 0.05；exchange transfusion，electrolyte disorders，the incidence of sinus bradycardia was significantly higher than that of the conventional group，P lt; 0.05；blood transfusion group compared to the conventional group hospital stay shorter，P lt; 0.05；the two groups before treatment，total bilirubin，indirect bilirubin，hemoglobin，P gt; 0.05；the two groups after the treatment of total bilirubin，indirect bilirubin decreased significantly，P lt; 0.05，but there was no significant difference between the groups，P gt; 0.05. While exchange transfusion，hemoglobin is obviously improved，the conventional group had no obvious change，P lt