高选择性吸附树脂在中药有效成分分离纯化中的应用研究.pdf

高选择性吸附树脂在中药有效成分分离纯化中的应用 1 夏建军，施荣富，杨益忠，王春红 (功能高分子材料教育部重点实验室, 南开大学高分子化学研究所, 天津, 300071) 摘要： 中药有效成分的提取纯化以及单体组分的分离是“中药现代化”研究中一个重要课题，高纯度提取物 及单体组分的制备是深入进行药理、药效、毒理研究的物质基础。吸附树脂法因其高效、高选择性、工艺简 单、环境友好等优点逐渐成为中草药等天然植物中有效成分分离纯化的重要方法。本文研究了高选择性吸附 树脂的结构设计方法，调节树脂孔结构、骨架性质、功能基、引入多重弱相互作用的协同效应，以期达到制 备高纯度提取物以及单体组分分离的目的。研究结果表明，高选择性吸附树脂在多种有效成分（如黄酮类、 生物碱类、皂甙类）的分离纯化中具有重要的作用，可成功制备多种高纯度提取物，所建立的提取工艺适用 于工业化生产，具有广泛的应用前景。 关键词：吸附树脂；中草药；协同效应；提取物 Application on the Separation and Purification of Principle Components in the Chinese Herbal Medicine Based on the High Selectivity Polymeric Adsorbent XIA Jian-jun ，SHI Rong-fu，YANG Yi-zhong ，WANG Chun-hong1 (Key Laboratory of Functional Polymer Materials, Ministry of Education,Institute of polymer chemistry, Nankai University, Tianjin 300071, China) Abstract ：Purification and separation of the activity components in the natural product will be one of the important problems for the studies on the modernization of Chinese Herbal medicine. High purity extract is the material foundation for the research of pharmacological, toxicological of medicine. In this paper, the structure controllable methods for the polymeric adsorbent were studied. By controlling the pore structure, 收稿日期： ∗联系人：王春红（1971-），女，副教授，主要从事吸附分离功能高分子材料合成及天然产物提取应用研究 E-mail ：wch2004@nankai.edu.cn improving the framework property and inducing the special functional groups, the resin with high selectivity could be synthesized based on the synergetic effect of several weak interactions. It was showed that the high selectivity resin could bring the important effect on the extract and purification of many kinds of active components from natural product, such as flavone, alkaloid, saponin, and so on. In addition, the adsorption extract technology will adapt to the