病理生理学（周平）复旦大学-2014 年 DIC八年制.pptxVIP

凝血与抗凝血平衡紊乱Coagulation anticoagulation disturbances向 萌Department of physiology and pathophysiologyShanghai medical schoolFudan University凝血与抗凝血的平衡抗凝血系统止血的过程抗凝血管痉挛凝血系统凝血血小板血栓形成纤溶纤维蛋白凝块形成纤溶系统COAGULATION CASCADEGeneral Features 1.Zymogens converted to enzymes by limited proteolysis2.Complex formation requiring calcium,phospholipid surface, cofactors ?3.Thrombin converts fibrinogen to fibrin monomer 4.Fibrin monomer crosslinked to fibrin forms glue for platelet plugEffect of platelets on blood coagulationThey present phospholipids on their surface that are essential for coagulation reactions.