结直肠癌Pgp、C－erbB－２蛋白表达的临床意义.docVIP

精品论文 参考文献 结直肠癌Pgp、C－erbB－２蛋白表达的临床意义 孙静阳１　吕申２　裴笑月１　孙海姣１　李晓慧１　胡波１ 　　１．大连大学附属新华医院病理科　辽宁　大连　１１６０２１;２．大连医科大学附属第二医院中心实验室　辽宁　大连　１１６０２１ 　　【摘要】　目的　C－erbB－２、Pgp蛋白表达与CRC临床病理特征的关系.方法　免疫组化检测蛋白表达,SPSS软件分析数据.结果　C－erbB－２蛋白表达与临床病理特征均无统计学相关性(P＞０．０５).Pgp蛋白表达在大体溃疡型(８６．８８％)与隆起型(７５．５１％)间统计学差异显著(P＜０．０５);在肿瘤侵润深度(肠壁浆膜层或累及临近器官９０．４８％、肠壁全层８８．４２％、肌层７２．２２％、粘膜下层６０％)间统计学差异显著(P＜０．０５);在淋巴结有无转移(９３．９８％,７５．９１％)间统计学差异特别显著(P＜０．０１).C－erbB－２与Pgp蛋白表达间无统计学相关性(P＞０．０５).结论　多数CRC可能有原发性多药耐药;Pgp蛋白可作反映CRC生物学行为的标志物,恶性程度较高的CRC可能易出现原发性多药耐药. 【关键词】　C－erbB－２　Pgp　结直肠癌　多药耐药TheClinicalSignificanceofC－erbB－２andPgpProteinExpressionsinColorectalCarcinoma　 【Abstract】Objective:ExplorethefeasibilitythatC－erbB－２andPgpproteinexpressionsareusedtoassessbiologicalbehaviorsandprognosisofcolorectalcancer．MethＧods:Immunohistochemistrywasusedtodetecttheproteinexpressions．SPSSstatisticsoftwarewasusedtoanalyzetherelationshipoftheproteinexpressionstoclinicalpathoＧlogicalfeaturesofthecancerandthecorrelationbetweentheproteinexpressions．Results:TheexpressionofC－erbB－２proteinhadnosignificantrelationstocharacteristicsofthecancers(P＞０．０５)．ThepositiveratesofPgpproteinexpressioningrossshapeofulcerandprotrusionwere８６．８８％and７５．５１％andtherewasstatisticalsignificancebetweenthem (P＜０．０５)．Thepositiveratesininvasionstoadjacentorgansorpenetrationserosa,toserosaoradventitia,tomuscleandtosubmucosawere９０．４８％,８８．４２％,７２．２２％and６０％respectivelyandtherewerestatisticalsignificancesamongthem(P＜０．０５)．Thepositiveratesintumorwithandwithoutlymphnodemetastasiswere９３．９８％and７５．９１％andtherewasstatisticalsignificancebetweenthem (P＜０．０１)．TherewerenostatisticalcorrelationsbetweenexpressionsofC－erbB－２andPgpproteinincolorectalcancer(P＞０．０５)．Conclusions:Themajorcolorectalcancersmighthaveaprimarymultidrugresistance．PgpproteincanbeseenasapotentialmarkerforjudgeＧment【mKaelyignWaonrtdsb】ehaviorofcolorectalcancerandthecolorectalcancerwithhighmalignancymighthavebigchancetobeprimarymultidrugresistance． C－erbB－２PgpCRCmultidrugresistance 【中图分类号】R７３５．３ 【文献标识码】B 　　【文章编号】１００８－６３１５(２０１５)１２－０３７５－