肝硬化患者凝血酶原时间和血小板参数的变化邓艳平.docVIP

精品论文 参考文献 肝硬化患者凝血酶原时间和血小板参数的变化邓艳平 湖南省长沙市第四医院检验科 410006 摘要：目的：观察肝硬化患者的凝血酶原时间和血小板检测，并分析探讨肝硬化患者凝血酶原时间和血小板参数的变化。方法：对106例研究对象进行凝血酶原时间检测，并进行血小板参数检测，包括平均血小板体积（MPV）、血小板计数（PLT）、血小板压积（PCT）、血小板分布宽度（PDW），其中64例肝硬化患者作为实验组，42例同期健康者作为对照组，同时对其凝血酶原时间、血小板参数检测结果分析，讨论变化情况。结果：在64例肝硬化患者中，凝血酶原时间明显延长，血小板参数检测MPV、PDW明显升高，PLT、PCT明显降低，结果与健康对照组有明显差异，差异有统计学意义（P＜0.05）。结论：与对照组相比，肝硬化患者的凝血酶原时间和血小板参数会有异常升高，凝血酶原时间和血小板参数能反映肝脏受损情况，两者的变化对肝硬化的临床诊断与治疗具有更重要的价值。 关键词：肝硬化；凝血酶原；血小板参数 【Abstract】 Objective：Observe the effects of thalidomide treatment of elderly patients and relapsed multiple myeloma clinical efficacy and effectiveness and safety，and to explore the most effective mechanism for the treatment of senile relapsed multiple myeloma.Method：clinical observation on 13 cases of primary treatment and 12 patients above 60 years of age with recurrent elderly myeloma patients，were made of arsenic trioxide combined with thalidomide treatment，intravenous arsenic trioxide for 10mg/d which，at the same time，the continuous injection 28 days，oral low dose thalidomide 100 200mmg/d，according to the actual situation of patients may be appropriate to increase，the maximum the limit is 300mg/d，28 days for a course of treatment，taking two courses of treatment，efficacy and side effects were observed during the evaluation of curative effect，in accordance with the standard EBM T effect，according to the NCI CTCAECTCAE（National Cancer Institute Common Terminology Criteria for Adverse Events，version 3）standard to evaluate the adverse reaction.Result：in the 13 patients newly diagnosed 5 cases of partial remission（38.46%），5 cases of progress（38.46%），and 3 cases ineffective（23.08%）.In 12 cases of senile multiple myeloma patients，4 cases of partial remission（33.3%），5 cases（41%）had improvement，3 cases（25%）are invalid，the total effective rate was 74.3%.Observed that，in the treatment of common adverse reactions are nausea and fatigue，abdominal distension and constipation，skin rash，liver injury，neutropenia，but after treatment wi