肺结核合并慢性乙肝病毒感染者40例治疗分析.docVIP

精品论文 参考文献 肺结核合并慢性乙肝病毒感染者40例治疗分析 河北省遵化市人民医院 河北 遵化 064200 摘要：目的 观察肺结核合并慢性乙肝病毒感染者抗结核同时抗乙肝病毒临床治疗效果。 方法 40例肺结核合并慢性乙肝病毒感染者随机分为对照组（甲组）20例，观察组（乙组））20例，观察组抗结核、保肝同时加用替比夫定抗病毒治疗，对照组抗结核同时单纯保肝治疗。结果 两组抗结核疗效无显著差异，观察组肝损害程度明显下降，治疗1-2个月时吡嗪酰胺对尿酸的增高程度明显下降。结论 肺结核合并慢性乙肝病毒感染者抗结核治疗同时加强抗病毒治疗有积极意义，值得推广应用。 关键词：肺结核 慢性乙肝病毒感染者 抗病毒治疗 【中图分类号】R822.1【文献标识码】A【文章编号】1001-5213(2016)09-0051-02 Therapy for chronic hepatitis b virus (HBV) infection 40 cases pulmonary tuberculosis were analyzed Zhou Guoyun Municipal People s Hospital Zunhua Hebei province China 064200 Abstract: Objective To observe the chronic hepatitis B virus infection of tuberculosis patients TB and anti-HBV effect of clinical treatment. Methods 40 cases of pulmonary tuberculosis complicated with chronic hepatitis B virus infection were randomly divided into control group (group A) in 20 cases, the observation group (group B)) in 20 cases, the observation group of anti-tuberculosis, hepatoprotective and telbivudine plus antiviral therapy, the control group and simple treatment of liver tuberculosis. Results there was no significant difference between two groups of anti-tuberculosis treatment, the observation group the degree of liver damage treatment decreased significantly, 1-2 months increased level of uric acid of pyrazinamide decreased significantly. Conclusion pulmonary tuberculosis complicated with chronic hepatitis B virus infection anti-tuberculosis treatment while strengthening the antiviral treatment has a positive meaning, it is worthy of popularization and application. Keywords: pulmonary tuberculosis patients with chronic hepatitis B virus infection and antiviral treatment 近年来肺结核合并慢性乙肝病毒感染患者常见，抗结核治疗不当，造成肝功能反复异常，不仅加重肝脏病变，又延误肺结核的治疗，给患者造成严重的经济及疾病负担，2010年1月-2015年12月我院对肺结核合并慢性乙肝病毒感染者加用替比夫定治疗，取得了满意疗效，现将结果报告如下 临 床 资 料 一、病例选择：40例患者均系我科肺结核合并慢性乙肝病毒感染（符合中华医学会传染病分会《慢乙肝治疗指南》定义）住院患者，甲组20例，其中男12例，女性8例，年龄18-64岁，平均年龄42.3岁，其中血型播散型肺结核2例，浸润性肺结核12例，慢性纤维空洞型肺结核4例，结核性渗出性胸膜炎2例；乙组20例，男性10例，女性10例，年龄19-65岁，平均年龄47.8岁，其中血