HA1077联合骨髓间充质干细胞治疗难愈创面观察.docVIP

HA1077联合骨髓间充质干细胞治疗难愈创面观察 204 [4] [5] [6] [7] [8] 誓(MedicalJoumaloftheChinesePeople§ArmedPoliceForces)Vo1.20N..032009—03出版 CumulativeNumberotConfirmedHumanCasesofAvian InfluenzaA/(H5N1)ReposedtoWHO.http://. /csr/disease/avian— influenza/country/cases— ta— ble_ 200605—— 23/en/index.html UngchusakK.Probableperson—to—persontransmis— sionofavianinfluenzaA(H5N1)[Jj.NEnglJMed, 2005,352(4):333 许庆华,王奉新,盂东平.层次分析法在防治SARS决 策中的应用[J].口岸卫生控制,2005,8(4):34 曾哲淳,赵冬,李岩.应用系统动力学模型对 SARS疫情传播及主要防控措施效果的计算机模拟仿 真研究[J].中华流行病学杂志,2005,26(3):159 ChunBC.Modellingtheimpactofpandemicinfluenza [J].JPrevMedPubHealth.2005,38(4):379 [9]Babakir—MinaM,BalestraE,PernoCFeta1.Practical problemsincontrollingH5N1highpathogenicityavian influenzaatvillagelevelinVietnamandintroductionof biosecuritymeasures[J].AvianDis,2007,51(Supp1): 461 [10]雷志勇,高宏生,伍瑞昌.禽流感人间大流行防控预 测研究现状[J].武警医学院,2006,15(5):397 [11]GermannTC,KadauK,LonginiaMeta1.Mitigation strategiesforpandemicinfluenzaintheUnitedStates [J].PNAS,2006,103(15):5935 (2008—07—31收稿,责任编辑梁秋野) HA1077联合骨髓问充质干细胞治疗难愈创面观察 刘贤华白晓东王佳哲.陈伟柳晓杰粟永萍(第三军医大学军事预防医学院防原医学教 研室,创伤,烧伤,复合伤国家重点实验室,重庆400038;武警总医院烧伤整形科,北京100039) 【摘要】目的将HA1077联合自体MSCs治疗慢性皮肤溃疡创面,观察能否促进创面愈合.方法体外分离人 MSCs.慢性皮肤创面病人4例,15个创面,随机分为对照组,HA1077组,细胞移植组.对照组,基本外科换药治疗.HA1077 组创面局部外用0.5mlHA1077注射液.细胞治疗组除HA1077治疗外,还局部应用骨髓间充质干细胞.治疗后3,7,14d计 算愈合指数(WCI).结果应用HA1077复合MSCs细胞组,在14d时的创面愈合指数为36.32±9.92,效果好于单纯应用 HA1077组和对照组,而HA1077组与对照组差别不大.结论HA1077可促进MSCs细胞修复慢性皮肤创面. 【关键词】HA1077骨髓间充质干细胞慢性创面【中国图书分类号】R632.1 TherapeuticapplicationofHA1077andMSCstoulcer LIUXianhua,BAIXiaodong,WANGJiazhe,CHENWei,LIUXiaojie,andSUYongping.StateKeyLaboratoryofTrauma,Burnsand CombinedInjury,InstituteofCombinedInjury,CollegeofPreventiveMedicine,ThirdMilitaryMedicalUniversity,Chongqing400038 【Abstract】ObjectiveToobservetheeffectsofhumanmesenchymalstemcells(MSCs)andHA1077onindolentulcerand woundhealing.MethodsHumanMSCswereseparatedinvitro.Fourwoundpatientswithrefractory15woundswereincluded.Control group(5wounds)wastreatedonlywithroutinedressing,HA1077groupwastreatedwit