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Peptic Ulcer Department of Gastroenterology and Hepatology The Second Affiliated Hospital Chongqing Medical University Introduction Definition: PU is ulceration which may occur at any site in the gastrointestinal tract that is exposed to acid-pepsin secretion. (“no acid, no ulcer.”) Defects in the gastrointestinal mucosa extending through the muscularis mucosae into the submucosa or muscularis Definition Ulcer : defects in the gastrointestinal mucosa penetrate the muscularis mucosa Erosion : small superficial mucosal lesions do not penetrate the muscularis mucosa
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